ArticlePloS one2018
Temporal trends in hyperuricaemia in the Irish health system from 2006-2014: A cohort study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Herbal medicine for asymptomatic hyperuricemia: a systematic review and network meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Dapagliflozin Added to Verinurad Plus Febuxostat Further Reduces Serum Uric Acid in Hyperuricemia: The QUARTZ Study.The Journal of clinical endocrinology and metabolism · 2021Trial
- Urate-lowering therapy in cardiovascular pharmacotherapy: from Mendelian randomization data to cardio-renal-metabolic risk modulation.European heart journal. Cardiovascular pharmacotherapy · 2026Review
- Association between exposure to proton pump inhibitors and hyperuricemia: risk prediction model establishment and nomogram construction.Frontiers in pharmacology · 2026Article
- Estimated glucose disposal rate and risk of incident hyperuricemia: insights from CHARLS.Scientific reports · 2025Article
- Uncovering Nonlinear Predictors of Serum Biomarker Uric Acid Using Interpretable Machine Learning in Healthy Men.Biomedicines · 2025Article
- Relationship between breakfast skipping and hyperuricemia in Korean adults: results from KNHANES 2016-2023.Scientific reports · 2025Article
- Hyperuricemia-Especially "Metabolic Hyperuricemia"-Is Independently Associated with a Higher Risk of Steatotic Liver Disease.Metabolites · 2025Article
- Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis.Biomedicines · 2025Article
- The effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults.Scientific reports · 2025Article
- A Hospital-Based, Single-Center, Cross-Sectional Study to Investigate theInternational journal of general medicine · 2025Article
- Innovative modeling: a diet-induced quail model for progressive pathological changes in uric acid metabolism disorders.Frontiers in nutrition · 2025Article
- Analysis of components and related risk factors of urinary stones: a retrospective study of 1055 patients in southern China.Scientific reports · 2024Article
- The Association of Dietary Diversity with Hyperuricemia among Community Inhabitants in Shanghai, China: A Prospective Research.Nutrients · 2024Article
- The association between visceral adipose accumulation and hyperuricemia risk among Chinese elder individuals: A nationwide prospective cohort study.Preventive medicine reports · 2024Article
- Hyperuricemia and its related diseases: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2024Review
- Targeting LiverPharmaceutics · 2024Article
- Correlation between remnant cholesterol and hyperuricemia in American adults.Lipids in health and disease · 2024Article
- Correlation between remnant cholesterol and hyperuricemia in patients with type 2 diabetes mellitus: a cross-sectional study.Lipids in health and disease · 2024Article
- Nonlinear relationship between oxidative balance score and hyperuricemia: analyses of NHANES 2007-2018.Nutrition journal · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated serum uric acid (sUA) concentrations are common in the general population and are associated with chronic metabolic conditions and adverse clinical outcomes. We evaluated secular trends in the burden of hyperuricaemia from 2006-2014 within the Irish health system.
methodsData from the National Kidney Disease Surveillance Programme was used to determine the prevalence of elevated sUA in adults, age > 18 years, within the Irish health system. Hyperuricaemia was defined as sUA > 416.4 μmol/L in men and > 339.06 μmol/L in women, and prevalence was calculated as the proportion of patients per year with mean sUA levels above sex-specific thresholds. Temporal trends in prevalence were compared from 2006 to 2014 while general estimating equations (GEE) explored variation across calendar years expressed as odds ratios (OR) and 95% Confidence intervals (CI).
resultsFrom 2006 to 2014, prevalence of hyperuricaemia increased from 19.7% to 25.0% in men and from 20.5% to 24.1% in women, P<0.001. The corresponding sUA concentrations increased significantly from 314.6 (93.9) in 2006 to 325.6 (96.2) in 2014, P<0.001. Age-specific prevalence increased in all groups from 2006 to 2014, and the magnitude of increase was similar for each age category. Adjusting for baseline demographic characteristics and illness indicators, the likelihood of hyperuricemia was greatest for patients in 2014; OR 1.45 (1.26-1.65) for men and OR 1.47 (1.29-1.67) in women vs 2006 (referent). Factors associated with hyperuricaemia included: worsening kidney function, elevated white cell count, raised serum phosphate and calcium levels, elevated total protein and higher haemoglobin concentrations, all P<0.001.
conclusionsThe burden of hyperuricaemia is substantial in the Irish health system and has increased in frequency over the past decade. Advancing age, poorer kidney function, measures of nutrition and inflammation, and regional variation all contribute to increasing prevalence, but these do not fully explain emerging trends.
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