ArticleNeurobiology of aging2018
Stable olfactory sensory neuron in vivo physiology during normal aging.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex.The journal of physiological sciences : JPS · 2024Review
- Natural and Pathological Aging Distinctively Impacts the Pheromone Detection System and Social Behavior.Molecular neurobiology · 2023Article
- Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats.The journal of physiological sciences : JPS · 2023Article
- Impaired olfactory neurogenesis affects the performance of olfactory-guided behavior in aged female opossums.Scientific reports · 2021Article
- Evaluation of olfactory bulbus volume and olfactory sulcus depth by 3 T MR.Surgical and radiologic anatomy : SRA · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Normal aging is associated with a number of smell impairments that are paralleled by age-dependent changes in the peripheral olfactory system, including decreases in olfactory sensory neurons (OSNs) and in the regenerative capacity of the epithelium. Thus, an age-dependent degradation of sensory input to the brain is one proposed mechanism for the loss of olfactory function in older populations. Here, we tested this hypothesis by performing in vivo optical neurophysiology in 6-, 12-, 18-, and 24-month-old mice. We visualized odor-evoked neurotransmitter release from populations of OSNs into olfactory bulb glomeruli, and found that these sensory inputs are actually quite stable during normal aging. Specifically, the magnitude and number of odor-evoked glomerular responses were comparable across all ages, and there was no effect of age on the sensitivity of OSN responses to odors or on the neural discriminability of different sensory maps. These results suggest that the brain's olfactory bulbs do not receive deteriorated input during aging and that local bulbar circuitry might adapt to maintain stable nerve input.
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Registered trials
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