ArticleBiomaterials2018
Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering.
Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Microengineered Gradient Hydrogels for Mechanobiology.Advanced healthcare materials · 2026Review
- Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis.Advanced healthcare materials · 2025Review
- Magnetic Hydrogels as a Treatment for Oncological Pathologies.Journal of functional biomaterials · 2025Review
- Continuous mechanical-gradient hydrogel with on-demand distributed MnBioactive materials · 2025Article
- Unveiling the Power of Magnetic-Driven Regenerative Medicine: Bone Regeneration and Functional Reconstruction.Research (Washington, D.C.) · 2025Review
- Evolving functional hydrogel strategies for cartilage engineering: from fundamentals to functional regeneration.Burns & trauma · 2025Review
- Physical-property-based patterning: simply engineering complex tissues.Trends in biotechnology · 2024Review
- Putting Hybrid Nanomaterials to Work for Biomedical Applications.Angewandte Chemie (International ed. in English) · 2024Review
- 3D printed osteochondral scaffolds: design strategies, present applications and future perspectives.Frontiers in bioengineering and biotechnology · 2024Review
- Cell unit-inspired natural nano-based biomaterials as versatile building blocks for bone/cartilage regeneration.Journal of nanobiotechnology · 2023Review
- Multifunctional hydrogels: advanced therapeutic tools for osteochondral regeneration.Biomaterials research · 2023Review
- Bioinspired gradient scaffolds for osteochondral tissue engineering.Exploration (Beijing, China) · 2023Review
- Recent development in multizonal scaffolds for osteochondral regeneration.Bioactive materials · 2023Review
- The Delivery and Activation of Growth Factors Using Nanomaterials for Bone Repair.Pharmaceutics · 2023Review
- Preparation and Characterization of Biomimetic Functional Scaffold with Gradient Structure for Osteochondral Defect Repair.Bioengineering (Basel, Switzerland) · 2023Review
- Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives.Bioactive materials · 2023Review
- From mesenchymal niches to engineeredMaterials today. Bio · 2022Article
- Tissue Engineering Cartilage with Deep Zone Cytoarchitecture by High-Resolution Acoustic Cell Patterning.Advanced healthcare materials · 2022Article
- Progress in Osteochondral Regeneration with Engineering Strategies.Annals of biomedical engineering · 2022Review
- Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury.RSC advances · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
In developmental biology, gradients of bioactive signals direct the formation of structural transitions in tissue that are key to physiological function. Failure to reproduce these native features in an in vitro setting can severely limit the success of bioengineered tissue constructs. In this report, we introduce a facile and rapid platform that uses magnetic field alignment of glycosylated superparamagnetic iron oxide nanoparticles, pre-loaded with growth factors, to pattern biochemical gradients into a range of biomaterial systems. Gradients of bone morphogenetic protein 2 in agarose hydrogels were used to spatially direct the osteogenesis of human mesenchymal stem cells and generate robust osteochondral tissue constructs exhibiting a clear mineral transition from bone to cartilage. Interestingly, the smooth gradients in growth factor concentration gave rise to biologically-relevant, emergent structural features, including a tidemark transition demarcating mineralized and non-mineralized tissue and an osteochondral interface rich in hypertrophic chondrocytes. This platform technology offers great versatility and provides an exciting new opportunity for overcoming a range of interfacial tissue engineering challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.