Evidence map›Paper›PMID 29852256›Full record

ArticleThe Journal of allergy and clinical immunology2019

Identification of galectin-3 as an autoantigen in patients with IgG

Cory A Perugino, Sultan B AlSalem, Hamid Mattoo, Emanuel Della-Torre, Vinay Mahajan, Gayathri Ganesh, Hugues Allard-Chamard, Zachary Wallace, Sydney B Montesi, Johannes Kreuzer and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 177 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. IgG4-Related Cholangitis.Seminars in liver disease · 2025
    Review
  8. Article
  9. Omics in IgG4-related disease.Chinese medical journal · 2025
    Review
  10. Review
  11. Review
  12. Review
  13. IgG4-related disease for the hematologist.Hematology. American Society of Hematology. Education Program · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. IL-1RA autoantibodies: insights into mechanisms and associated diseases.American journal of translational research · 2024
    Review
  19. Review
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Cory A PeruginoDivision of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Ragon Institute of MGH, MIT and Harvard, Cambridge, Mass.
Sultan B AlSalemRagon Institute of MGH, MIT and Harvard, Cambridge, Mass; Department of Dermatology, King Saud University College of Medicine, Riyadh, Saudi Arabia.
Hamid MattooRagon Institute of MGH, MIT and Harvard, Cambridge, Mass.
Emanuel Della-TorreRagon Institute of MGH, MIT and Harvard, Cambridge, Mass; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS-San Raffaele Scientific Institute, Milan, Italy.
Vinay MahajanRagon Institute of MGH, MIT and Harvard, Cambridge, Mass; Division of Pathology, Brigham and Women's Hospital, Boston, Mass.
Gayathri GaneshRagon Institute of MGH, MIT and Harvard, Cambridge, Mass.
Hugues Allard-ChamardRagon Institute of MGH, MIT and Harvard, Cambridge, Mass.
Zachary WallaceDivision of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Sydney B MontesiDivision of Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, Mass.
Johannes KreuzerMassachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, Mass.
Wilhelm HaasMassachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, Mass.
John H StoneDivision of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Shiv PillaiDivision of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Ragon Institute of MGH, MIT and Harvard, Cambridge, Mass. Electronic address: spillai@mgh.harvard.edu.
Ragon Institute of MGH, MIT and Harvard · USMassachusetts General Hospital · USBrigham and Women's Hospital · USHarvard University · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
The importance of the IgG4 glycome in IgG4-related disease(s)U19AI110495 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 2014 to 2026
$7.9M
Research Training in Rheumatology at Massachusetts General HospitalT32AR007258 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1986 to 2026
$6.9M
Pathogenesis of IgG4 related diseaseK08AI113163 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MAHAJAN, VINAY SUBHASH · 2014 to 2018
$953k
Translational Immunology Core's FACSAria Cell SorterS10RR023440 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI PREFFER, FREDERIC IRA · 2008 to 2008
$500k
NCRR NIH HHS S10 RR023440NIAID NIH HHS K08 AI113163NIAID NIH HHS U19 AI110495NIAMS NIH HHS T32 AR007258NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

backgroundThe antigenic trigger that drives expansion of circulating plasmablasts and CD4

objectiveWe sought to sequence immunoglobulin genes from single-cell clones of dominantly expanded plasmablasts and generate recombinant human mAbs to identify relevant antigens in patients with IgG

methodsPaired heavy and light chain cDNAs from dominant plasmablast clones were expressed as mAbs and used to purify antigens by using immunoaffinity chromatography. Affinity-purified antigens were identified by using mass spectrometry and validated by means of ELISA. Plasma levels of the antigen of interest were also determined by using ELISA.

resultsmAbs expressed from the 2 dominant plasmablast clones of a patient with multiorgan IgG

conclusionAffinity chromatography using patient-derived mAbs identifies relevant autoantigens in patients with IgG

Indexed as

AutoantibodiesAutoantigensCD4-Positive T-LymphocytesCell ProliferationFemaleGalectin 3HumansImmunoglobulin EImmunoglobulin GImmunoglobulin G4-Related DiseaseImmunoglobulinsImmunosorbent TechniquesLymphocyte ActivationMaleMass SpectrometryMiddle AgedAutoantibodiesAutoantigensGalectin 3Immunoglobulin EImmunoglobulin GImmunoglobulinsRecombinant Proteinsautoantibodyautoantigengalectin-3IgG(4)-related diseaseplasmablast

Identifiers

PMID29852256
PMCPMC6265117
OpenAlexW2807281772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.