Evidence map›Paper›PMID 29852022›Full record

ReviewPLoS genetics2018

Outstanding questions in the study of archaic hominin admixture.

Aaron B Wolf, Joshua M Akey

Abstract readReview
In one paragraph

Review in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  7. Review
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  11. Review
  12. Large-scale functional screen identifies genetic variants with splicing effects in modern and archaic humans.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Predicting Archaic Hominin Phenotypes from Genomic Data.Annual review of genomics and human genetics · 2022
    Review
  15. Apportioning archaic variants among modern populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aaron B WolfDepartment of Genome Sciences, University of Washington, Seattle, Washington, United States of America.ORCID 0000-0002-9401-0765
Joshua M AkeyDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.

Funding

Identification and interpretation of introgressed hominin DNA in modern human genomesR01GM110068 · NIGMS · UNIVERSITY OF WASHINGTON · PI AKEY, JOSHUA MICHAEL · 2014 to 2024
$2.6M
NIGMS NIH HHS R01 GM110068NIH HHS R01GM110068
6 · The paper itself

Abstract

The complete sequencing of archaic and modern human genomes has revolutionized the study of human history and evolution. The application of paleogenomics has answered questions that were beyond the scope of archaeology alone-definitively proving admixture between archaic and modern humans. Despite the remarkable progress made in the study of archaic-modern human admixture, many outstanding questions remain. Here, we review some of these questions, which include how frequent archaic-modern human admixture was in history, to what degree drift and selection are responsible for the loss and retention of introgressed sequences in modern human genomes, and how surviving archaic sequences affect human phenotypes.

Indexed as

Evolution, MolecularAdaptation, BiologicalAnimalsGene FlowGenetics, PopulationGenome, HumanHominidaeHumansModels, GeneticSequence Analysis, DNA

Identifiers

PMID29852022
PMCPMC5978786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.