Evidence map›Paper›PMID 29851868›Full record

ArticlePsychosomatic medicine

Anticipatory Effects on Perceived Pain: Associations With Development and Anxiety.

Kalina J Michalska, Julia S Feldman, Rany Abend, Andrea L Gold, Troy C Dildine, Esther E Palacios-Barrios, Ellen Leibenluft, Kenneth E Towbin, Daniel S Pine, Lauren Y Atlas

Open access · greenAbstract read
In one paragraph

Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
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  4. [AI in rehabilitation-application of artificial mental models for personalized medicine].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025
    Review
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  7. Human ventromedial prefrontal cortex lesions enhance the effect of expectations on pain perception.Cortex; a journal devoted to the study of the nervous system and behavior · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kalina J MichalskaFrom the Department of Psychology (Michalska), University of California Riverside, Riverside, California; Department of Psychology (Feldman, Palacios-Barrios), University of Pittsburgh, Pittsburgh, Pennsylvania; The National Institute of Mental Health, Emotion and Development Branch (Abend, Gold, Leibenluft, Towbin, Pine); National Center for Complementary and Integrative Health (Dildine, Atlas), Bethesda, Maryland; Department of Clinical Neuroscience (Dildine), Karolinska Institutet, Stockholm, Sweden; and National Institute on Drug Abuse (Atlas), Baltimore, Maryland.
Julia S Feldman
Rany Abend
Andrea L Gold
Troy C Dildine
Esther E Palacios-Barrios
Ellen Leibenluft
Kenneth E Towbin
Daniel S Pine
Lauren Y Atlas
Swedish Veterinary Agency · SE

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Effects of external ear stimulation on pain perception and moodZIAAT000032 · NCCIH · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · PI SHURTLEFF, DAVID · 2016 to 2025
$5.9M
Neural and psychological mechanisms of pain perception ZIAAT000030 · NCCIH · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · PI ATLAS, LAUREN · 2015 to 2025
$3.8M
fMRI Study Of Risk Of Mood/Anxiety Disorders In ChildrenZ01MH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.7M
Fmri Studies Of Pediatric Mood And Anxiety DisordersZ01MH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.5M
Intramural NIH HHS Z01 MH002781Intramural NIH HHS Z01 MH002782Intramural NIH HHS ZIA AT000032Intramural NIH HHS ZIA MH002781NCCIH NIH HHS ZIA AT000032
6 · The paper itself

Abstract

objectiveNaturalistic studies suggest that expectation of adverse experiences such as pain exerts particularly strong effects on anxious youth. In healthy adults, expectation influences the experience of pain. The current study uses experimental methods to compare the effects of expectation on pain among adults, healthy youth, and youth with an anxiety disorder.

methodsTwenty-three healthy adults, 20 healthy youth, and 20 youth with an anxiety disorder underwent procedures in which auditory cues were paired with noxious thermal stimulation. Through instructed conditioning, one cue predicted low-pain stimulation and the other predicted high-pain stimulation. At test, each cue was additionally followed by a single temperature calibrated to elicit medium pain ratings. We compared cue-based expectancy effects on pain across the three groups, based on cue effects on pain elicited on medium heat trials.

resultsAcross all groups, as expected, participants reported greater pain with increasing heat intensity (β = 2.29, t(41) = 29.94, p < .001). Across all groups, the critical medium temperature trials were rated as more painful in the high- relative to low-expectancy condition (β = 1.72, t(41) = 10.48, p < .001). However, no evidence of between-group differences or continuous associations with age or anxiety was observed.

conclusionsAll participants showed strong effects of expectancy on pain. No influences of development or anxiety arose. Complex factors may influence associations among anxiety, development, and pain reports in naturalistic studies. Such factors may be identified using experiments that employ more complex, yet controlled manipulations of expectancy or assess neural correlates of expectancy.

Indexed as

AdolescentAdolescent DevelopmentAdultAnticipation, PsychologicalAnxiety DisordersAuditory PerceptionChildChild DevelopmentFemaleHot TemperatureHumansMaleNociceptive PainPain PerceptionPhysical StimulationYoung Adult

Identifiers

PMID29851868
PMCPMC7675786
OpenAlexW2805781498

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.