ReviewMedicine2018
IgG4-related fibrosing mediastinitis diagnosed with computed tomography-guided percutaneous needle biopsy: Two case reports and a review of the literature.
Review in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Surgical management of recurrent spinal hypertrophic pachymeningitis: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Interventional treatment of refractory pleural effusion secondary to radiotherapy-induced fibrosing mediastinitis: A case report.SAGE open medical case reports · 2026Article
- Presentation of Superior Vena Cava Syndrome as a Consequence of Fibrosing Mediastinitis.Cureus · 2026Article
- Article
- Fibrosing Mediastinitis in a 5-Year-Old Labrador Retriever.Veterinary medicine and science · 2025Article
- Pharmacological Management of IgG4-Related Disease: From Traditional to Mechanism-Based Targeted Therapies.Drugs & aging · 2025Review
- Venous retrograde approach for endovascular angioplasty in chronic total pulmonary vein occlusion -a case report.BMC cardiovascular disorders · 2024Article
- Bronchial artery embolization combined with left pulmonary resection in the treatment of fibrosing mediastinitis complicated with massive hemoptysis: a case report.Frontiers in medicine · 2024Article
- Renal Manifestations of IgG4-Related Disease: A Concise Review.International journal of nephrology · 2024Review
- CT andThe Journal of international medical research · 2023Article
- Thoracic manifestations of IgG4-related disease.Respirology (Carlton, Vic.) · 2023Review
- Pictorial review of computed tomography and magnetic resonance imaging findings of cardiovascular manifestations of IgG4-related disease.Polish journal of radiology · 2023Review
- Recurrent haemoptysis: a rare diagnosis of kaposiform lymphangiomatosis and review of literature.BMJ case reports · 2022Article
- Extensive fibrotic wrapping of the heart: a rare echocardiographic diagnosis.Cardiovascular ultrasound · 2022Article
- IgG4-associated fibrosing mediastinitis requiring differentiation from posterior mediastinal tumour: A case report.Respirology case reports · 2022Article
- Pulmonary Hypertension Caused by Fibrosing Mediastinitis.JACC. Asia · 2022Review
- Comparison of fibrosing mediastinitis patients with vs. without markedly increased systolic pulmonary arterial pressure: a single-center retrospective study.BMC cardiovascular disorders · 2022Article
- Article
- Clinical Features of Fibrosing Mediastinitis in Japanese Patients: Two Case Reports and a Literature Review.Internal medicine (Tokyo, Japan) · 2021Review
- Idiopathic fibrous mediastinitis with refractory pleural effusion: a case report and literature review.The Journal of international medical research · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleImmunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory disease characterized by elevated serum IgG4 levels with infiltration of IgG4+ plasma cells and severe fibrosis in affected tissues. Recently, idiopathic fibrosing mediastinitis (FM), an extremely rare fibroinflammatory disorder, has been recognized as a form of IgG4-RD. As IgG4-RD can be treated by glucocorticoids, identification of the etiology of FM by surgical biopsy is essential; however, mediastinal biopsy is often difficult. We report 2 cases of IgG4-related FM successfully diagnosed with computed tomography (CT)-guided percutaneous needle biopsy. PATIENT CONCERNS: Case 1 was a 66-year-old woman with elevated serum C-reactive protein without any symptoms and case 2 was 78-year-old woman with abnormal mediastinal contour on chest x-ray. By further work-up, both cases were found to have mediastinitis accompanied by elevated serum IgG4. CT-guided percutaneous needle biopsy revealed massive infiltration of IgG4+plasma cells along with storiform fibrosis. DIAGNOSIS: IgG4-related FM.
interventionsGlucocorticoid therapy. OUTCOME: The treatment resulted in significant improvement of the lesions after 3 months. LESSONS: Early recognition and diagnosis of IgG4-related FM is essential because a delay in appropriate treatment initiation leads to progressive fibrosis with irreversible organ damage and poor prognosis. Our cases highlight CT-guided percutaneous needle biopsy as a promising option for histological examination in patients with IgG4-related FM.
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