Evidence map›Paper›PMID 29851460›Full record

ArticleACS nano2018

Nanosensors for the Chemical Imaging of Acetylcholine Using Magnetic Resonance Imaging.

Yi Luo, Eric H Kim, Chris A Flask, Heather A Clark

Abstract read
In one paragraph

Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. A molecular probe for detecting cholinesterase activity in MRI.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Structural and functional imaging of brains.Science China. Chemistry · 2023
    Review
  10. Review
  11. Review
  12. Molecular fMRI of neurochemical signaling.Journal of neuroscience methods · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Magnetic Nanoparticles as MRI Contrast Agents.Topics in current chemistry (Cham) · 2020
    Review
  17. Magnetic Nanoparticles Supporting Bio-responsiveMaterials (Basel, Switzerland) · 2019
    Review
  18. Recent Developments in Nanosensors for Imaging Applications in Biological Systems.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yi LuoDepartment of Pharmaceutical Sciences , Northeastern University , Boston , Massachusetts 02115 , United States.ORCID 0000-0003-4652-9666
Eric H KimDepartment of Bioengineering , Northeastern University , Boston , Massachusetts 02115 , United States.ORCID 0000-0002-9787-848X
Chris A FlaskDepartments of Radiology, Biomedical Engineering, and Pediatrics , Case Western Reserve University , Cleveland , Ohio 44106 , United States.
Heather A ClarkDepartment of Bioengineering , Northeastern University , Boston , Massachusetts 02115 , United States.ORCID 0000-0002-2628-9194
Northeastern University · USCase Western Reserve University · US

Funding

Polymer-Free Nanosensors To Visualize Biochemical Dynamics in Dendritic SpinesR01NS081641 · NINDS · NORTHEASTERN UNIVERSITY · PI CLARK, HEATHER A · 2013 to 2017
$1.6M
NINDS NIH HHS R01 NS081641
6 · The paper itself

Abstract

A suite of imaging tools for detecting specific chemicals in the central nervous system could accelerate the understanding of neural signaling events critical to brain function and disease. Here, we introduce a class of nanoparticle sensors for the highly specific detection of acetylcholine in the living brain using magnetic resonance imaging. The nanosensor is composed of acetylcholine-catalyzing enzymes and pH-sensitive gadolinium contrast agents co-localized onto the surface of polymer nanoparticles, which leads to changes in T

Indexed as

Magnetic Resonance ImagingAcetylcholineAnimalsBrainContrast MediaGadoliniumHydrogen-Ion ConcentrationMaleModels, MolecularMolecular ImagingMolecular StructureNanoparticlesParticle SizePolymersRatsRats, Sprague-DawleyAcetylcholineContrast MediaGadoliniumPolymersacetylcholinebiosensorsMRI contrast agentsnanosensorneurotransmitter

Identifiers

PMID29851460
PMCPMC6281809
OpenAlexW2805042830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.