Evidence map›Paper›PMID 29851339›Full record

ArticleJournal of chemical information and modeling2018

Exploring Substrate Binding in the Extracellular Vestibule of MhsT by Atomistic Simulations and Markov Models.

Ara M Abramyan, Matthias Quick, Catherine Xue, Jonathan A Javitch, Lei Shi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ara M AbramyanComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse - Intramural Research Program , National Institutes of Health , Baltimore , Maryland 21224 , United States.
Matthias QuickDivision of Molecular Therapeutics , New York State Psychiatric Institute , New York , New York 10032 , United States.
Catherine XueComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse - Intramural Research Program , National Institutes of Health , Baltimore , Maryland 21224 , United States.
Jonathan A JavitchDivision of Molecular Therapeutics , New York State Psychiatric Institute , New York , New York 10032 , United States.
Lei ShiComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse - Intramural Research Program , National Institutes of Health , Baltimore , Maryland 21224 , United States.ORCID 0000-0002-4137-096X
National Institutes of Health · USNew York Psychoanalytic Society and Institute · US

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI NAKAMOTO, ROBERT K. · 2010 to 2017
$31.9M
Structural basis for the functions of dopamine receptors, neurotransmitter transporters, and sigma 1 receptorZIADA000606 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SHI, LEI · 2015 to 2025
$20.5M
Probing mechanisms of amphetamine action at plasma membrane and vesicular transporters in vitro and in vivoR01DA041510 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JAVITCH, JONATHAN A · 2017 to 2021
$2.7M
Intramural NIH HHS Z99 DA999999Intramural NIH HHS ZIA DA000606NIDA NIH HHS R01 DA041510NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

Neurotransmitter:sodium symporters (NSS) terminate neurotransmission through Na

Indexed as

BacillusBacterial ProteinsBinding SitesMarkov ChainsMolecular Docking SimulationMolecular Dynamics SimulationPlasma Membrane Neurotransmitter Transport ProteinsProtein BindingProtein ConformationSubstrate SpecificityBacterial ProteinsPlasma Membrane Neurotransmitter Transport Proteins

Identifiers

PMID29851339
PMCPMC6159221
OpenAlexW2807506601

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.