Evidence map›Paper›PMID 29851141›Full record

ArticleMagnetic resonance in medicine2019

Assessment of frequency drift on CEST MRI and dynamic correction: application to gagCEST at 7 T.

Johannes Windschuh, Moritz Zaiss, Philipp Ehses, Jae-Seung Lee, Alexej Jerschow, Ravinder R Regatte

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
  2. Review
  3. Article
  4. Rapid and simplified post-processing for simultaneousMagnetic resonance in medicine · 2025
    Article
  5. Review
  6. Human liver CEST imaging at 7 T: Impact ofMagnetic resonance in medicine · 2025
    Article
  7. RF Heating Effects in CEST NMR with HyperpolarizedChemphyschem : a European journal of chemical physics and physical chemistry · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. BTomography (Ann Arbor, Mich.) · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Johannes WindschuhNew York University Langone Medical Center, Department of Radiology, Center for Biomedical Imaging, New York, New York.
Moritz ZaissMax Planck Institute for Biological Cybernetics, High-Field Magnetic Resonance Center, Tübingen, Germany.
Philipp EhsesGerman Center for Neurodegenerative Diseases, Department of MR Physics, Bonn, Germany.
Jae-Seung LeeNew York University Langone Medical Center, Department of Radiology, Center for Biomedical Imaging, New York, New York.ORCID 0000-0002-8571-0663
Alexej JerschowNew York University, Department of Chemistry, New York, New York.
Ravinder R RegatteNew York University Langone Medical Center, Department of Radiology, Center for Biomedical Imaging, New York, New York.

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dmitry S Novikov · 2014 to 2026
$19.3M
Imaging Biomarkers of Knee OsteoarthritisR01AR068966 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2016 to 2021
$3.1M
Sodium MRI for Assessment of Early OA.R01AR060238 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2011 to 2015
$2.9M
Cartilage, Bone and Marrow Interactions in Knee OAR01AR056260 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2010 to 2014
$2.5M
Assessment of Cartilage Repair with Sodium MRI at 3TR01AR067156 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2015 to 2019
$2.3M
Quantitative MRI for Early Diagnosis of ArthritisR01AR053133 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2007 to 2011
$1.8M
Isolating CEST from MT Asymmetry in MRIR01EB016045 · NIBIB · NEW YORK UNIVERSITY · PI JERSCHOW, ALEXEJ · 2013 to 2016
$1.4M
National Institutes of Health (NIH) R01-AR060238National Institutes of Health (NIH) R01-AR067156National Institutes of Health (NIH) R01-AR068966National Institutes of Health (NIH) R01EB016045NIAMS NIH HHS R01 AR053133NIAMS NIH HHS R01 AR056260NIAMS NIH HHS R01 AR060238NIAMS NIH HHS R01 AR067156NIAMS NIH HHS R01 AR068966NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB016045
6 · The paper itself

Abstract

purposeTo investigate the effect of a frequency drift of the static magnetic field on 3D CEST MRI based on glycosaminoglycans (GAGs) of articular cartilage at 7 T and to introduce a retrospective correction method that uses the phase images of the gradient-echo readout.

methodsRepeated gagCEST and B

resultsThe frequency drift of the MRI scanner strongly influences the gagCEST signal in the articular cartilage of the human knee joint. The gagCEST signal in the articular cartilage is changed by 0.18%/Hz while an average drift of 0.7 ± 0.2 Hz/minute was observed. The proposed correction method can be applied retrospectively without the need of additional measurements and provides improved comparability and reproducibility for gagCEST studies. This correction method may also be of interest for other applications of CEST MRI.

conclusionProspective or retrospective correction of the frequency drift of the MRI scanner is essential for reproducible gagCEST measurements. The proposed retrospective correction method fulfills this requirement without the need of additional measurements.

Indexed as

Magnetic FieldsMagnetic Resonance ImagingAdultAlgorithmsBlood GlucoseCartilage, ArticularContrast MediaFemaleGlycosaminoglycansHealthy VolunteersHumansImage Processing, Computer-AssistedImaging, Three-DimensionalKnee JointMalePhantoms, ImagingBlood GlucoseContrast MediaGlycosaminoglycansProtons

Identifiers

PMID29851141
PMCPMC6258338

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.