Evidence map›Paper›PMID 29850990›Full record

Trial reportEuropean journal of nutrition2019

Influence of 4-week multi-strain probiotic administration on resting-state functional connectivity in healthy volunteers.

Deepika Bagga, Christoph Stefan Aigner, Johanna Louise Reichert, Cinzia Cecchetto, Florian Ph S Fischmeister, Peter Holzer, Christine Moissl-Eichinger, Veronika Schöpf

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 51 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07439978 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Physiological Study of a Fermented Yogurt Drink Containing Probiotics

TypeinterventionalSponsorUniversity College DublinRan2026 to 2026Enrolled50ConditionsColonization, Asymptomatic, ColonisationArmsprobiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
NCT07510282 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Physiological Study on How Probiotic Delivered to the Small Intestine Changes Microbiota

TypeinterventionalSponsorUniversity College DublinRan2026 to 2026Enrolled25ConditionsColonization, Asymptomatic, ColonizationArmsProbiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
NCT07679490 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

A Physiological Study of a Fruit Snack Containing Probiotics

TypeinterventionalSponsorUniversity College DublinRan2026 to 2027Enrolled25ConditionsColonization, Asymptomatic, Probiotic Intervention, Gut Microbiota Diversity and Composition, Gut-brain AxisArmsMicroencapsulated Lactobacillus rhamnosus Fruit Snack, Placebo Fruit Snack
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deepika BaggaInstitute of Psychology, University of Graz, Universitätsplatz 2, 8010, Graz, Austria.
Christoph Stefan AignerInstitute of Medical Engineering, Graz University of Technology, Graz, Austria.
Johanna Louise ReichertInstitute of Psychology, University of Graz, Universitätsplatz 2, 8010, Graz, Austria.
Cinzia CecchettoInstitute of Psychology, University of Graz, Universitätsplatz 2, 8010, Graz, Austria.
Florian Ph S FischmeisterInstitute of Psychology, University of Graz, Universitätsplatz 2, 8010, Graz, Austria.
Peter HolzerBioTechMed, Graz, Austria.
Christine Moissl-EichingerBioTechMed, Graz, Austria.
Veronika SchöpfInstitute of Psychology, University of Graz, Universitätsplatz 2, 8010, Graz, Austria. veronika.schoepf@uni-graz.at.ORCID http://orcid.org/0000-0003-1937-4216

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExperimental investigations in rodents have contributed significantly to our current understanding of the potential importance of the gut microbiome and brain interactions for neurotransmitter expression, neurodevelopment, and behaviour. However, clinical evidence to support such interactions is still scarce. The present study used a double-blind, randomized, pre- and post-intervention assessment design to investigate the effects of a 4-week multi-strain probiotic administration on whole-brain functional and structural connectivity in healthy volunteers.

methodsForty-five healthy volunteers were recruited for this study and were divided equally into three groups (PRP: probiotic, PLP: placebo, and CON: control). All the participants underwent resting-state functional MRI and diffusion MRI brain scans twice during the course of study, at the beginning (time point 1) and after 4 weeks (time point 2). MRI data were acquired using a 3T whole-body MR system (Magnetom Skyra, Siemens, Germany).

resultsFunctional connectivity (FC) changes were observed in the default mode network (DMN), salience network (SN), and middle and superior frontal gyrus network (MFGN) in the PRP group as compared to the PLP and CON groups. PRP group showed a significant decrease in FC in MFGN (in frontal pole and frontal medial cortex) and in DMN (in frontal lobe) as compared to CON and PLP groups, respectively. Further, significant increase in FC in SN (in cingulate gyrus and precuneus cortex) was also observed in PRP group as compared to CON group. The significance threshold was set to p < 0.05 FWE corrected. No significant structural differences were observed between the three groups.

conclusionsThis work provides new insights into the role of a multi-strain probiotic administration in modulating the behaviour, which is reflected as changes in the FC in healthy volunteers. This study motivates future investigations into the role of probiotics in context of major depression and stress disorders.

Indexed as

AdultBrainDouble-Blind MethodFemaleHealthy VolunteersHumansMagnetic Resonance ImagingMaleProbioticsReference ValuesRestYoung AdultDiffusionGut–brain axisMRIProbioticsResting-stateSalience

Identifiers

PMID29850990
PMCPMC6647073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.