ArticleRheumatology international2018
Endothelial dysfunction in patients with granulomatosis with polyangiitis: a case-control study.
Article in Rheumatology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Arterial Stiffness and Adult Onset Vasculitis: A Systematic Review.Frontiers in medicine · 2022Pooled it
- From ANCA-mediated vascular injury to coronary microvascular and myocardial involvement in granulomatosis with polyangiitis: an immunocardiology perspective.Rheumatology international · 2026Review
- ANCA-associated vasculitis is associated with an increased risk of cardiac and vascular morbidity: results of a large-scale propensity-matched global retrospective cohort study.Frontiers in immunology · 2026Article
- Evaluating subclinical atherosclerosis, arterial stiffness, and lipid profile in patients with anti neutrophilic cytoplasmic antibodies associated vasculitis: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Article
- Malignancy in systemic lupus erythematosus: relation to disease characteristics in 92 patients - a single center retrospective study.Rheumatology international · 2024Article
- Post-stroke rehabilitation in the peri-pandemic COVID-19 era.Rheumatology international · 2024Review
- Arterial Stiffness as a Surrogate Marker of Cardiovascular Disease and Atherosclerosis in Patients with Vasculitides: A Literature Review.Diagnostics (Basel, Switzerland) · 2023Review
- Impact of Cardiovascular Risk Factors on the Occurrence of Cardiovascular Events in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitides.Journal of clinical medicine · 2021Article
- Endothelial dysfunction in patients with systemic sclerosis.Postepy dermatologii i alergologii · 2020Article
- Endothelial dysfunction in patients with eosinophilic granulomatosis with polyangiitis.Clinical rheumatology · 2019Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundGranulomatosis with polyangiitis (GPA) is a rare granulomatous vasculitis affecting small- and medium-sized blood vessels. In optimally treated patients with long-standing disease, the common cause of death is atherosclerosis even in the absence of typical risk factors.
objectiveTo evaluate endothelial dysfunction in GPA patients.
methods44 patients (21 men and 23 women) diagnosed with GPA and 53 controls matched for age, sex, BMI and typical risk factors for cardiovascular diseases (22 men and 31 women) were enrolled in the study. We measured each participant's serum levels of vascular cell adhesion molecule-1 (VCAM-1), interleukin 6 (IL-6), and thrombomodulin. We also studied flow-mediated dilatation (FMD) of the brachial artery, intima-media thickness (IMT) of the common carotid artery and aortic stiffness using echocardiography.
resultsPatients with GPA showed a 15.9% increase in serum levels of VCAM-1 (p = 0.01), 66% of IL-6 (p < 0.001) and 50.9% of thrombomodulin (p < 0.001) compared to controls. FMD% was 48.9% lower in patients with GPA in comparison to controls (p < 0.001), after adjustment for potential confounders, with no differences regarding IMT or aortic stiffness. FMD% was negatively associated with duration of the disease (β = - 0.18 [95% CI: - 0.32 to - 0.04]), C-reactive protein (β = - 0.17 [95% CI: - 0.27 to - 0.07]), IL-6 (β = - 0.29 [95% CI: - 0.39 to - 0.19]), blood creatinine level (β = - 0.2 [95% CI: - 0.3 to - 0.1]), and IMT (β = - 0.14 (- 0.24 to - 0.04). In a multiple linear regression model, kidney function, IMT, pack-years of smoking, diabetes and level of VCAM-1 were independent predictors of lower FMD%.
conclusionGPA is characterized by endothelial dysfunction. FMD is a useful tool for the detection of endothelial injury.
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