Trial reportAnnals of surgical oncology2018
1 Versus 2-cm Excision Margins for pT2-pT4 Primary Cutaneous Melanoma (MelMarT): A Feasibility Study.
Trial report in Annals of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02385214 (A Phase III, Multi-centre, Multi-national Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase III, Multi-centre, Multi-national Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Narrow Excision Margins for Diverse Histological Subtypes of Cutaneous Melanoma in Children and Adults: A Systematic Review.Dermatology and therapy · 2026Pooled it
- A systematic review of patient-reported outcome measures for advanced skin cancer patients.Archives of dermatological research · 2023Pooled it
- Review
- Advances in the treatment of cutaneous tumors: from conventional therapies to targeted and immunotherapeutic strategies.World journal of surgical oncology · 2026Review
- Variation in the Surgical Care of Early Stage Melanoma Based on Surgical Subspecialty: Evaluation of Large Healthcare System.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026Article
- Evaluating LLMs in non-metastatic melanoma care: a comparative analysis.Frontiers in medicine · 2026Article
- [Value of surgery for malignant melanoma in the context of current adjuvant and neoadjuvant treatment concepts].Dermatologie (Heidelberg, Germany) · 2025Review
- Comparison of 1-cm Versus 2-cm Excision Margins for Cutaneous Melanoma: A Systematic Review and Meta-Analysis.Cureus · 2025Review
- Article
- Phase-specific and laser-modulated polydopamine-chlorella-curdlan hydrogels: pioneering a melanoma integrative therapy.Theranostics · 2025Article
- Management of Localized Melanoma in the Anti-PD-1 Era.Current oncology reports · 2024Review
- A Review of Contemporary Guidelines and Evidence for Wide Local Excision in Primary Cutaneous Melanoma Management.Cancers · 2024Review
- Surgical resection margin for T3-T4 primary acral melanoma: a multicenter retrospective cohort study.Archives of dermatological research · 2023Article
- The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients-Experience of a Single Clinic.Diagnostics (Basel, Switzerland) · 2023Article
- Surgical Management of Melanoma: Advances and Updates.Current oncology reports · 2022Review
- Fifty years of progress in surgical oncology: Melanoma.Journal of surgical oncology · 2022Article
- Melanoma trials that defined surgical management: Overview of trials that established NCCN margin guidelines.Journal of surgical oncology · 2022Review
- 'Primum non nocere': how harmless is routine wide local excision for AJCC stage IA melanoma?Annals of the Royal College of Surgeons of England · 2020Article
- Primary Melanoma: from History to Actual Debates.Current oncology reports · 2019Review
- Sentinel Lymph Node Biopsy and Complete Lymph Node Dissection for Melanoma.Current oncology reports · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
24 authors at 16 institutions in 5 countries.
Funding
Abstract
backgroundThere is a lack of consensus regarding optimal surgical excision margins for primary cutaneous melanoma > 1 mm in Breslow thickness (BT). A narrower surgical margin is expected to be associated with lower morbidity, improved quality of life (QoL), and reduced cost. We report the results of a pilot international study (MelMarT) comparing a 1 versus 2-cm surgical margin for patients with primary melanoma > 1 mm in BT.
methodsThis phase III, multicentre trial [NCT02385214] administered by the Australia & New Zealand Medical Trials Group (ANZMTG 03.12) randomised patients with a primary cutaneous melanoma > 1 mm in BT to a 1 versus 2-cm wide excision margin to be performed with sentinel lymph node biopsy. Surgical closure technique was at the discretion of the treating surgeon. Patients' QoL was measured (FACT-M questionnaire) at baseline, 3, 6, and 12 months after randomisation.
resultsBetween January 2015 and June 2016, 400 patients were randomised from 17 centres in 5 countries. A total of 377 patients were available for analysis. Primary melanomas were located on the trunk (56.9%), extremities (35.6%), and head and neck (7.4%). More patients in the 2-cm margin group required reconstruction (34.9 vs. 13.6%; p < 0.0001). There was an increased wound necrosis rate in the 2-cm arm (0.5 vs. 3.6%; p = 0.036). After 12 months' follow-up, no differences were noted in QoL between groups. DISCUSSION: This pilot study demonstrates the feasibility of a large international RCT to provide a definitive answer to the optimal excision margin for patients with intermediate- to high-risk primary cutaneous melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.