ArticleInternational archives of occupational and environmental health2018
An increase of fractional exhaled nitric oxide after specific inhalation challenge is highly predictive of occupational asthma.
Article in International archives of occupational and environmental health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Mechanistic and Therapeutic Approaches to Occupational Exposure-Associated Allergic and Non-Allergic Asthmatic Disease.Current allergy and asthma reports · 2023Review
- Occupational Respiratory Allergy: Risk Factors, Diagnosis, and Management.Handbook of experimental pharmacology · 2022Article
- Fractional exhaled nitric oxide levels in relation to work-related respiratory burden and sensitization to wheat flour and multigrain in bakers.Clinical and translational allergy · 2021Article
- Serial measurements of fractional exhaled nitric oxide at home and at work: A useful tool for monitoring workers with platinum salt allergy after exposure reduction.Health science reports · 2021Article
- Epigenetic Markers Are Associated With Differences in Isocyanate Biomarker Levels in Exposed Spray-Painters.Frontiers in genetics · 2021Article
- Article
- Progress in Occupational Asthma.International journal of environmental research and public health · 2020Review
- Prevention of baker's asthma.Current opinion in allergy and clinical immunology · 2020Review
- Non-invasive tools beyond lung function before and after specific inhalation challenges for diagnosing occupational asthma.International archives of occupational and environmental health · 2019Article
- Update on the Management of Occupational Asthma and Work-Exacerbated Asthma.Allergy, asthma & immunology research · 2019Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAn increase of fractional exhaled nitric oxide (FeNO) has been described after specific inhalation challenges (SICs) with occupational allergens, but the clinical role of FeNO measurements before and after SIC is unknown. It was the aim of this study to assess the diagnostic accuracy of FeNO measurements before and after SIC in subjects with suspected occupational asthma (OA).
methodsOne hundred forty-eight patients with suspected OA were examined by SIC with various occupational allergens. Subjects were assigned to pulmonary responders, nonresponders or doubtful by standard lung function criteria. FeNO was measured before SIC (baseline) and 24 h afterwards. Subjects with negative or doubtful SIC but increase of FeNO were evaluated individually by an overall expert rating. Effect modifiers of FeNO increases were assessed by regression analyses.
resultsThirty-one patients (21%) were classified as pulmonary responders, 105 (71%) as nonresponders and 12 (8%) as doubtful. With the pulmonary responder status as gold standard an increase of FeNO ≥ 13 ppb showed a specificity of 0.9 and a sensitivity of 0.5. Seventeen subjects with negative or doubtful responder status showed such an increase of FeNO, among them 13 subjects with definitive or probable OA after expert rating. Regression analyses revealed no significant modifiers for the FeNO increase.
conclusionAn increase of FeNO after SIC is highly predictive of OA and should be regarded as an additional criterion for the interpretation of SIC with occupational agents.
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