ArticleInternational journal of colorectal disease2018
The effect of gender on early colonic anastomotic wound healing.
Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Anastomotic leak risk factors following colon cancer resection: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2023Pooled it
- Non-steroidal Anti-inflammatory Drugs and Timing-specific Anastomotic Leak Risk Following Minimally Invasive Proctectomy: A Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- Exposure to androgen deprivation therapy and risk of anastomotic leakage after colorectal cancer surgery.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Prophylactic defunctioning stomas improve clinical outcomes of anastomotic leak following rectal cancer resections: An analysis of the US Rectal Cancer Consortium.International journal of colorectal disease · 2024Article
- Topical Neuropeptide Y for Ischemic Skin Wounds.International journal of molecular sciences · 2024Article
- Relative decline in serum albumin help to predict anastomotic leakage for female patients following sphincter-preserving rectal surgery.BMC surgery · 2023Article
- Exposure to oestrogen and risk of anastomotic leakage after colorectal cancer surgery - A clue to the different leak rates in men and women.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2023Observational
- Development and validation of a nomogram to predict anastomotic leakage in colorectal cancer based on CT body composition.Frontiers in nutrition · 2022Article
- Updates of Risk Factors for Anastomotic Leakage after Colorectal Surgery.Diagnostics (Basel, Switzerland) · 2021Review
- A Human Cellular Model for Colorectal Anastomotic Repair: The Effect of Localization and Transforming Growth Factor-β1 Treatment on Collagen Deposition and Biomarkers.International journal of molecular sciences · 2021Article
- Sex differences in murine myocutaneous flap revascularization.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2020Article
- Glucagon-Like Peptide-2 Analogue ZP1849 Augments Colonic Anastomotic Wound Healing.Gastroenterology research and practice · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClinically, male patients subjected to colorectal surgery are more prone to develop anastomotic leakage than female patients by unknown mechanisms. Our aim was to investigate the impact of gender on anastomotic wound healing using an experimental model.
methodsOne-layer colonic anastomosis was constructed in 8-week-old 28 male and 32 female Sprague-Dawley rats. Animals of one group (n = 30) were sacrificed immediately after surgery day 0 and the other group (n = 30) on postoperative day 3. Anastomotic breaking strength, total collagen (hydroxyproline), soluble collagen (Sircol), matrix metalloproteinase (MMP)-9, and transforming growth factor (TGF)-β1 were measured.
resultsThe anastomotic breaking strength decreased from day 0 to day 3 with no significant gender differences either in the extent of decline (P = 0.122) or absolute day 3 strengths (P = 0.425). Analogously, total collagen concentration in the anastomotic wounds decreased postoperatively and were lower (P = 0.043) in the male compared with the female rats on day 3. MMP-9 levels increased in the anastomoses postoperatively, but they did not differ (P = 0.391) between male and female animals. Soluble collagen levels were lower in the day-3 anastomoses of male versus female rats (P = 0.015) and correlated positively with total TGF-β1 levels (r
conclusionOur findings point towards a less favorable collagen metabolism in colonic anastomoses of male compared with female rats during early wound healing.
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