ArticleSchizophrenia bulletin2019
Dysregulated Maturation of the Functional Connectome in Antipsychotic-Naïve, First-Episode Patients With Adolescent-Onset Schizophrenia.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin.Molecular psychiatry · 2024Trial
- Brain functional connectivity associated with cognitive deficits in younger patients at first episode of schizophrenia.Schizophrenia research. Cognition · 2025Article
- Schizophrenia and Neurodevelopment: Insights From Connectome Perspective.Schizophrenia bulletin · 2025Review
- The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study.Schizophrenia (Heidelberg, Germany) · 2024Article
- Impaired large-scale cortico-hippocampal network connectivity, including the anterior temporal and posterior medial systems, and its associations with cognition in patients with first-episode schizophrenia.Frontiers in neuroscience · 2023Article
- Abnormal global-brain functional connectivity and its relationship with cognitive deficits in drug-naive first-episode adolescent-onset schizophrenia.Brain imaging and behavior · 2022Article
- Modular-level alterations of single-subject gray matter networks in schizophrenia.Brain imaging and behavior · 2022Article
- Age-associated network controllability changes in first episode drug-naïve schizophrenia.BMC psychiatry · 2022Article
- Involvement of cerebellar and subcortical connector hubs in schizophrenia.NeuroImage. Clinical · 2022Article
- Frequency-specific altered global signal topography in drug-naïve first-episode patients with adolescent-onset schizophrenia.Brain imaging and behavior · 2021Article
- Early-Stage Repetitive Transcranial Magnetic Stimulation Altered Posterior-Anterior Cerebrum Effective Connectivity in Methylazoxymethanol Acetate Rats.Frontiers in neuroscience · 2021Article
- Individual-specific functional connectome biomarkers predict schizophrenia positive symptoms during adolescent brain maturation.Human brain mapping · 2020Article
- Transdiagnostic Dysfunctions in Brain Modules Across Patients with Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Connectome-Based Study.Schizophrenia bulletin · 2020Article
- Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia.Schizophrenia bulletin · 2020Article
- MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.Frontiers in human neuroscience · 2020Article
- Functional network connectivity impairments and core cognitive deficits in schizophrenia.Human brain mapping · 2019Article
- Brain function, structure and genomic data are linked but show different sensitivity to duration of illness and disease stage in schizophrenia.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSchizophrenia has been conceptualized as a brain network disorder rooted in dysregulated neurodevelopmental processes. Recent neuroimaging studies revealed disrupted brain connectomic organization in adult schizophrenia patients. However, altered developmental trajectories of the functional connectome during the adolescent maturational stage have not been examined.
methodsThe present study combined functional MRI with a graph theoretical approach to examine functional network topology and its age-related development in 39 medication naïve, first-episode patients with adolescent-onset schizophrenia and 31 matched controls (age range: 12-18 years).
resultsPatients demonstrated impaired large-scale integration as reflected by reduced global efficiency as well as decreased regional nodal efficiency in highly integrative network hubs, most consistently the hippocampal formation and the precuneus. Furthermore, the left hippocampus showed opposite age-efficiency associations in healthy controls and patients, indicating dysregulated maturational trajectories in adolescent schizophrenia and a particular vulnerability of this region during early pathological attack.
conclusionsThe findings allow an integrative perspective on network and neurodevelopmental perspectives on schizophrenia, suggesting that dysregulated maturation of the functional connectome during adolescence might reflect an early marker for the disorder.
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