Evidence map›Paper›PMID 29850877›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2019

Evaluating the Prediction of Brain Maturity From Functional Connectivity After Motion Artifact Denoising.

Ashley N Nielsen, Deanna J Greene, Caterina Gratton, Nico U F Dosenbach, Steven E Petersen, Bradley L Schlaggar

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026
    Article
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  6. Review
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  11. Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ashley N NielsenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Deanna J GreeneDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Caterina GrattonDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Nico U F DosenbachDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Steven E PetersenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Bradley L SchlaggarDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
TRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2M
STRUCTURE, FUNCTION AND COGNITION IN SCHIZOPHRENIAP50MH071616 · NIMH · WASHINGTON UNIVERSITY · PI THOMPSON, PAUL A. · 2004 to 2008
$11.2M
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
DEVELOPMENT OF SKILLED READING: FMRI STUDIESR01HD057076 · NICHD · WASHINGTON UNIVERSITY · PI SCHLAGGAR, BRADLEY L · 2008 to 2012
$1.7M
The Study of Task-Level Control Signals Using fMRIR01NS046424 · NINDS · WASHINGTON UNIVERSITY · PI PETERSEN, STEVEN E. · 2003 to 2006
$1.4M
Unilateral Hearing Loss in ChildrenK23DC006638 · NIDCD · WASHINGTON UNIVERSITY · PI LIEU, JUDITH EUNKYUNG CHO · 2005 to 2009
$886k
PEDIATRIC BRAIN INJURY RECOVERY VIA USE-DRIVEN FUNCTIONAL NETWORK REORGANIZATIONK23NS088590 · NINDS · WASHINGTON UNIVERSITY · PI DOSENBACH, NICO · 2015 to 2019
$886k
PREDICTING OUTCOME IN CHILDREN WITH TIC DISORDERS USING NEUROIMAGING DATAK01MH104592 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2014 to 2018
$723k
PREDICTING OUTCOME IN CHILDREN WITH NEW-ONSET TICS USING NEUROIMAGING DATAR21NS091635 · NINDS · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J, SCHLAGGAR, BRADLEY L · 2015 to 2016
$419k
LONGITUDINAL EFFECTS OF TREATMENT ON BRAIN FUNCTION IN CHILDREN WITH TOURETTE SYNR21MH091512 · NIMH · WASHINGTON UNIVERSITY · PI SCHLAGGAR, BRADLEY L · 2010 to 2011
$416k
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NICHD NIH HHS R01 HD057076NICHD NIH HHS U54 HD087011NIDCD NIH HHS K23 DC006638NIDDK NIH HHS P60 DK020579NIMH NIH HHS K01 MH104592NIMH NIH HHS P50 MH071616NIMH NIH HHS R21 MH091512NINDS NIH HHS F32 NS092290NINDS NIH HHS K23 NS088590NINDS NIH HHS R01 NS046424NINDS NIH HHS R21 NS091635
6 · The paper itself

Abstract

The ability to make individual-level predictions from neuroanatomy has the potential to be particularly useful in child development. Previously, resting-state functional connectivity (RSFC) MRI has been used to successfully predict maturity and diagnosis of typically and atypically developing individuals. Unfortunately, submillimeter head motion in the scanner produces systematic, distance-dependent differences in RSFC and may contaminate, and potentially facilitate, these predictions. Here, we evaluated individual age prediction with RSFC after stringent motion denoising. Using multivariate machine learning, we found that 57% of the variance in individual RSFC after motion artifact denoising was explained by age, while 4% was explained by residual effects of head motion. When RSFC data were not adequately denoised, 50% of the variance was explained by motion. Reducing motion-related artifact also revealed that prediction did not depend upon characteristics of functional connections previously hypothesized to mediate development (e.g., connection distance). Instead, successful age prediction relied upon sampling functional connections across multiple functional systems with strong, reliable RSFC within an individual. Our results demonstrate that RSFC across the brain is sufficiently robust to make individual-level predictions of maturity in typical development, and hence, may have clinical utility for the diagnosis and prognosis of individuals with atypical developmental trajectories.

Indexed as

ArtifactsAdolescentAdultBrainBrain MappingChildFemaleHumansImage Processing, Computer-AssistedMachine LearningMagnetic Resonance ImagingMaleMotionNeural PathwaysYoung AdultdevelopmentfMRIfunctional connectivitymachine learning

Identifiers

PMID29850877
PMCPMC6519700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.