Evidence map›Paper›PMID 29850871›Full record

ArticleEuropean heart journal2018

International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology.

Jelena-Rima Ghadri, Ilan Shor Wittstein, Abhiram Prasad, Scott Sharkey, Keigo Dote, Yoshihiro John Akashi, Victoria Lucia Cammann, Filippo Crea, Leonarda Galiuto, Walter Desmet and 26 more

4 registry-linked trialsAbstract readConsensus Statement
In one paragraph

Article in European heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 786 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
786citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04695587 unknown statusnot on this mapstarted 2019, after this paper: background citation

The Role of Sympathetic Tone Regarding the Anatomical and Functional Recovery of the Left Ventricle in TakoTsubo Syndrome

TypeobservationalSponsorHippocration General HospitalRan2019 to 2023Enrolled30ConditionsTakotsubo CardiomyopathyArms123 MIBG scintigraphy testing, MSNA, ABPM, ECHO, 24hour ECG
NCT05731830 recruitingnot on this mapstarted 2022, after this paper: background citation

Takotsubo Syndrome and Air Pollution: the "Tako-Air" Study

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2022 to 2026Enrolled250ConditionsTakotsubo SyndromeArmsData extraction, Clinical follow-up
NCT05793008 narecruitingnot on this mapstarted 2023, after this paper: background citation

Characterization of priMary And sEcondary STress Related takOtsubo: the MAESTRO Pilot Study

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2023 to 2026Enrolled60ConditionsTakotsubo Cardiomyopathy, Sepsis-induced CardiomyopathyArmsPositron Emission Tomography (PET) analysis, Blood samples collection, Clinical follow up visit
NCT05977049 narecruitingnot on this mapstarted 2024, after this paper: background citation

Psychosocial Support for Patients With Takotsubo Syndrome

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2024 to 2027Enrolled24ConditionsTakotsubo CardiomyopathyArmsTakotsubo Support Group
3 · Its place in the literature

Who cites it

786 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Sympathetic nerve activity and response to physiological stress in Takotsubo syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Trial
  5. Mechanical circulatory support for cardiogenic shock in takotsubo syndrome.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  6. Article
  7. New insights into takotsubo syndrome: results from a multicenter cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  8. Article
  9. Article
  10. Cocaine-induced acute myocardial infarction: angiographic features and outcomes.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  11. A novel parameter for risk stratification in patients with takotsubo syndrome.American heart journal plus : cardiology research and practice · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

726 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Jelena-Rima GhadriUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Ilan Shor WittsteinDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abhiram PrasadDivision of Cardiovascular Diseases Mayo Clinic, Rochester, MN, USA.
Scott SharkeyCardiovascular Research Division, Minneapolis Heart Institute Foundation, Minneapolis, MN, USA.
Keigo DoteDepartment of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan.
Yoshihiro John AkashiDivision of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Victoria Lucia CammannUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Filippo CreaDepartment of Cardiovascular Sciences, Catholic University of the Sacred Heart, Rome, Italy.
Leonarda GaliutoDepartment of Cardiovascular Sciences, Catholic University of the Sacred Heart, Rome, Italy.
Walter DesmetDepartment of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium.
Tetsuro YoshidaDepartment of Cardiovascular Medicine, Onga Nakama Medical Association Onga Hospital, Fukuoka, Japan.
Roberto ManfrediniClinica Medica, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Ingo EitelUniversity Heart Center Luebeck, Medical Clinic II, Department of Cardiology, Angiology and Intensive Care Medicine, University of Luebeck, Luebeck, Germany.
Masami KosugeDivision of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.
Holger M NefDepartment of Cardiology, University Hospital Giessen, Giessen, Germany.
Abhishek DeshmukhDivision of Cardiovascular Diseases Mayo Clinic, Rochester, MN, USA.
Amir LermanDivision of Cardiovascular Diseases Mayo Clinic, Rochester, MN, USA.
Eduardo BossoneHeart Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.
Rodolfo CitroHeart Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.
Takashi UeyamaDepartment of Anatomy and Cell Biology, Wakayama Medical University School of Medicine, Wakayama, Japan.
Domenico CorradoDepartment of Cardiac, Thoracic, and Vascular Sciences, University of Padua Medical School, Padova, Italy.
Satoshi KurisuDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Frank RuschitzkaUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
David WinchesterDivision of Cardiovascular Disease, Department of Medicine, University of Florida, Gainesville, FL, USA.
Alexander R LyonNIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.
Elmir OmerovicDepartment of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Patrick MeimounDepartment of Cardiology and Intensive Care, Centre Hospitalier de Compiegne, Compiegne, France.
Guiseppe TarantiniDepartment of Cardiac, Thoracic, and Vascular Sciences, University of Padua Medical School, Padova, Italy.
Charanjit RihalDivision of Cardiovascular Diseases Mayo Clinic, Rochester, MN, USA.
Shams Y-HassanDepartment of Cardiology, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Federico MiglioreDepartment of Cardiac, Thoracic, and Vascular Sciences, University of Padua Medical School, Padova, Italy.
John D HorowitzDepartment of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
Hiroaki ShimokawaDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Thomas Felix LüscherCenter for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland.
Christian TemplinUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology. This consensus also proposes new diagnostic criteria based on current knowledge to improve diagnostic accuracy.

Indexed as

Age DistributionCatecholaminesCoronary Artery DiseaseCoronary VasospasmHumansMental DisordersMicrocirculationNervous System DiseasesPlaque, AtheroscleroticRisk FactorsSex DistributionTakotsubo CardiomyopathyTerminology as TopicCatecholamines

Identifiers

PMID29850871
PMCPMC5991216

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.