ArticleCerebral cortex (New York, N.Y. : 1991)2019
Functional Fractionation of the Cingulo-opercular Network: Alerting Insula and Updating Cingulate.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heterogeneous brain alterations in treatment-resistant depression converge on common control networks.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Pooled it
- Connecting memory and functional brain networks in older adults: a resting-state fMRI study.GeroScience · 2023Trial
- New functional insights from the monkey claustrum.National science review · 2026Review
- MCI-LB brain networks reorganization in relation to specific cognitive domains deficits.Scientific reports · 2026Article
- Salient Memory: Effects of Distributed Learning on Cortical Regions During Memory Retrieval.Human brain mapping · 2025Article
- Task-Switch Related Reductions in Neural Distinctiveness in Children and Adults: Commonalities and Differences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Functional and Structural Alterations in Pediatric Multiple Sclerosis: A Systematic Review and a Preliminary Activation Likelihood Estimation Functional Magnetic Resonance Imaging Meta-Analysis.Pediatric reports · 2025Review
- Youth Generalized Anxiety and Brain Activation States During Socioemotional Processing.JAMA psychiatry · 2025Article
- EEG-Based Micro-Expression Recognition: Flexible Brain Network Reconfiguration Supporting Micro-Expressions Under Positive Emotion.Psychology research and behavior management · 2025Article
- Executive Function Associations With Audibility-Adjusted Speech Perception in Noise.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Changes in hoarding-related beliefs and associated neural changes during a simulated discarding task after cognitive-behavioral treatment for hoarding disorder.Journal of psychiatric research · 2024Article
- Low-intensity focused ultrasound to the insula differentially modulates the heartbeat-evoked potential: A proof-of-concept study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Intrinsic functional networks for distinct sources of error in visual working memory.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- From movement to motivation: a proposed framework to understand the antidepressant effect of exercise.Translational psychiatry · 2024Review
- Same, Same but Different? A Multi-Method Review of the Processes Underlying Executive Control.Neuropsychology review · 2024Review
- Higher Intersubject Variability in Neural Response to Narrative Social Stimuli Among Youth With Higher Social Anxiety.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Initial learning in the brain: From rules to action.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Specialized late cingulo-opercular network activation elucidates the mechanisms underlying decisions about ambiguity.NeuroImage · 2023Article
- Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking.Addiction neuroscience · 2023Article
- The Involvement of the Multiple Demand and Default Mode Networks in a Trial-by-Trial Cognitive Control.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The anterior insula (AI) and dorsal anterior cingulate cortex (dACC) are engaged in various cognitive and affective processes. An influential account posits that the AI and dACC's ubiquitous engagements reflect their role in the transient capture of attention by salient stimuli. Using fMRI here we tested this claim and functionally dissociated these regions. In the first experiment, we compared these regions' responses to emotion-laden and emotion-neutral salient "oddball" movie events. We found that while the AI only responded transiently to the onset and offset of neutral events, its response to affective events was sustained, challenging the transient attention capture account. By contrast, dACC remained transient regardless of event type. A second experiment distinguished the information encoded by these brain regions with the presentation of behaviorally salient events that require either maintaining the current task set or updating to a different one; the AI was found to signal the presence of the behaviorally relevant events, while the dACC was associated with switching of attention settings in response to the events. We conclude that AI and dACC are involved in signaling the presence of potentially or de facto behaviorally significant events and updating internal attention settings in response to these events, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.