Evidence map›Paper›PMID 29850528›Full record

ArticleBioMed research international2018

miR-144-5p Enhances the Radiosensitivity of Non-Small-Cell Lung Cancer Cells via Targeting ATF2.

Lei Song, Liping Peng, Shucheng Hua, Xiaoping Li, Lianjun Ma, Jing Jie, Dong Chen, Ying Wang, Dan Li

Abstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Identification of Tumor SuppressiveInternational journal of molecular sciences · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Application of nano-radiosensitizers in combination cancer therapy.Bioengineering & translational medicine · 2023
    Review
  15. Article
  16. Article
  17. Analysis of miRNA Expression Profiling ofInternational journal of molecular sciences · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lei SongDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID 0000-0002-4115-065X
Liping PengDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID 0000-0001-7369-4048
Shucheng HuaDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Xiaoping LiDepartment of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Lianjun MaEndoscopy Center, The China-Japan Union Hospital of Jilin University, 146 Xiantai Street, Changchun, Jilin 130021, China.
Jing JieDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Dong ChenDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Ying WangDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Dan LiDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID 0000-0002-3036-2374

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs or miRs) regulate gene expression at the posttranscriptional level and are involved in many biological processes such as cell proliferation and migration, stem cell differentiation, inflammation, and apoptosis. In particular, miR-144-3p is downregulated in various cancers, and its overexpression inhibits the proliferation and metastasis of cancer cells. However, the role of miR-144-5p in non-small-cell lung cancer (NSCLC), especially radiosensitivity, is unknown. In this study, we found that miR-144-5p was downregulated in NSCLC clinical specimens as well as NSCLC cell lines exposed to radiation. Enhanced expression of miR-144-5p promoted the radiosensitivity of NSCLC cells

Indexed as

Activating Transcription Factor 2AnimalsApoptosisBase SequenceCarcinoma, Non-Small-Cell LungCell Line, TumorCell SurvivalGene Expression Regulation, NeoplasticHumansLung NeoplasmsMaleMice, Inbred BALB CMice, NudeMicroRNAsRadiation, IonizingRadiation ToleranceActivating Transcription Factor 2ATF2 protein, humanMicroRNAsMIRN144 microRNA, human

Identifiers

PMID29850528
PMCPMC5925000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.