Evidence map›Paper›PMID 29850502›Full record

ArticleBioMed research international2018

A Single Codon Optimization Enhances Recombinant Human TNF-

Chu Chu, Wangqian Zhang, Jialin Li, Yi Wan, Zenglu Wang, Ruyi Duan, Pei Yu, Ning Zhao, Kuo Zhang, Shuning Wang and 7 more

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Chu ChuState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Wangqian ZhangState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Jialin LiState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Yi WanShaanxi Institute of Microbiology, Xi'an 710043, China.ORCID 0000-0002-0275-9374
Zenglu WangState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0001-9512-8960
Ruyi DuanState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Pei YuState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Ning ZhaoState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Kuo ZhangState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Shuning WangState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Qiang HaoState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Weina LiState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Cun ZhangState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Wei ZhangState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Yingqi ZhangState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Meng LiDepartment of Pharmacogenomics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0002-8000-3003
Xiaochang XueState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0001-9718-4659
Air Force Medical University · CNMicrobiology Institute of Shaanxi · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a proinflammatory cytokine, tumor necrosis factor-alpha (TNF-

Indexed as

Amino Acid SequenceAnimalsAntibodiesAntigensCodonEpitopes, T-LymphocyteEscherichia coliHumansMice, Inbred C57BLNeutralization TestsNucleic Acid ConformationRecombinant ProteinsRNA, MessengerTumor Necrosis Factor-alphaVaccines, SyntheticAntibodiesAntigensCodonEpitopes, T-LymphocyteRecombinant ProteinsRNA, MessengerTumor Necrosis Factor-alphaVaccines, Synthetic

Identifiers

PMID29850502
PMCPMC5925214
OpenAlexW2797238386

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.