ArticleMicrobial cell (Graz, Austria)2018
Evolution of substrate specificity in the Nucleobase-Ascorbate Transporter (NAT) protein family.
Article in Microbial cell (Graz, Austria), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 28 citations in OpenAlex.
- Deciphering the Diversity in Bacterial Transporters That Salvage Queuosine Precursors.Epigenomes · 2024Article
- Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations.Pflugers Archiv : European journal of physiology · 2023Article
- Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter.Nature communications · 2023Article
- The evolution of vitamin C biosynthesis and transport in animals.BMC ecology and evolution · 2022Article
- Specific Residues in a Purine Transporter Are Critical for Dimerization, ER Exit, and Function.Genetics · 2019Article
- Tales of tails in transporters.Open biology · 2019Review
- NAT/NCS2-hound: a webserver for the detection and evolutionary classification of prokaryotic and eukaryotic nucleobase-cation symporters of the NAT/NCS2 family.GigaScience · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-ascorbic acid (vitamin C) is an essential metabolite in animals and plants due to its role as an enzyme co-factor and antioxidant activity. In most eukaryotic organisms, L-ascorbate is biosynthesized enzymatically, but in several major groups, including the primate suborder Haplorhini, this ability is lost due to gene truncations in the gene coding for L-gulonolactone oxidase. Specific ascorbate transporters (SVCTs) have been characterized only in mammals and shown to be essential for life. These belong to an extensively studied transporter family, called Nucleobase-Ascorbate Transporters (NAT). The prototypic member of this family, and one of the most extensively studied eukaryotic transporters, is UapA, a uric acid-xanthine/H
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Registered trials
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