Evidence map›Paper›PMID 29850442›Full record

ArticleJournal of reproduction & infertility

The Efficacy and Safety of On-demand Tramadol and Paroxetine Use in Treatment of Life Long Premature Ejaculation: A Randomized Double-blind Placebo-controlled Clinical Trial.

Ali Hamidi-Madani, Reza Motiee, Gholamreza Mokhtari, Hamidreza Nasseh, Samaneh Esmaeili, Ehsan Kazemnezhad

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of reproduction & infertility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 6 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 6 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  6. Safety and efficacy of "on-demand" tramadol in patients with premature ejaculation: an updated meta-analysis.International braz j urol : official journal of the Brazilian Society of Urology
    Pooled it
  7. Ferulic Acid: A Review of Mechanisms of Action, Absorption, Toxicology, Application on Wound Healing.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ali Hamidi-Madani- Urology Research Center, School of Medicine, Razi hospital, Guilan University of Medical Sciences, Rasht, Iran.
Reza Motiee- Urology Research Center, School of Medicine, Razi hospital, Guilan University of Medical Sciences, Rasht, Iran.
Gholamreza Mokhtari- Urology Research Center, School of Medicine, Razi hospital, Guilan University of Medical Sciences, Rasht, Iran.
Hamidreza Nasseh- Urology Research Center, School of Medicine, Razi hospital, Guilan University of Medical Sciences, Rasht, Iran.
Samaneh Esmaeili- Urology Research Center, School of Medicine, Razi hospital, Guilan University of Medical Sciences, Rasht, Iran.
Ehsan Kazemnezhad- Urology Research Center, School of Medicine, Razi hospital, Guilan University of Medical Sciences, Rasht, Iran.
Guilan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral medical therapies have been proposed for the treatment of premature ejaculation (PE). Paroxetine and tramadol were both reported to be effective in treatment of PE. In this study, the therapeutic effects of tramadol, paroxetine and placebo were compared in treatment of primary PE.

methodsIn this randomized, double-blind, placebo-controlled clinical trial, 150 patients were divided into 3 groups. One group was treated with tramadol 50

resultsAt the end of the 12th week, the mean IELT and average of PEP scores improved in all 3 groups. The increase in tramadol group was significantly higher than the paroxetine and placebo groups (p<0.0001). There were no significant differences in terms of side effects between the 3 groups.

conclusionThe results showed that despite an increase in mean IELT and PEP scores in all 3 groups, the rate of improvement in tramadol group was significantly more than the others. Thus, tramadol may be considered as an appropriate alternative therapeutic option for lifelong PE.

Indexed as

IELTParoxetinePEPPremature ejaculationTramadol

Identifiers

PMID29850442
PMCPMC5960046
OpenAlexW2785284231

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.