ArticleCardiovascular diagnosis and therapy2018
Kounis syndrome induced by amoxicillin following vasospastic coronary event in a 22-year-old patient: a case report.
Article in Cardiovascular diagnosis and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Kounis Syndrome: Review of Clinical Cases.Cardiovascular & hematological disorders drug targets · 2024Review
- Clinical features, diagnosis and management of amoxicillin-induced Kounis syndrome.Frontiers in pharmacology · 2022Article
- Case report: Cefoperazone-sulbactam induced Kounis syndrome and cardiogenic shock.Frontiers in cardiovascular medicine · 2022Article
- Cardiac arrest in type II Kounis syndrome after oral intake of amoxicilline.American journal of cardiovascular disease · 2020Article
- Vasospastic coronary event following a single dose of amoxicillin in a patient with normal coronary arteries: Kounis syndrome and the myocardial infarction with normal coronary arteries conundrum.Cardiovascular diagnosis and therapy · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
This article reports the case of a 22-year-old male patient presented with electrocardiographic ST elevation and elevated cardiac biomarkers. The clinical cascade set into events within an hour of administration of a single-dose of amoxicillin on being diagnosed with acute tonsillitis. The case was preliminarily diagnosed and treated according to the acute coronary syndrome protocol, but on performing coronary angiography no abnormalities in the coronary artery were found. Acute myocarditis was excluded in cardiac MRI. Considering possible hypersensitive reaction of amoxicillin in the absence of major cardiovascular risk in the young patient, diagnosis of Kounis syndrome (KS) was inferred. A thorough clinical observation of the patient after stopping the administration of amoxicillin revealed that there was a resolution of ST-elevation towards baseline. It coincided with falling cardiac biomarkers concomitant with subsided pain. The asymptomatic patient was discharged after 5 days of hospital stay. Telephonic follow-up one week after discharge from the hospital confirmed his pain-free and overall normal clinical status. Aim of the present report is to emphasize the need for increased awareness of KS induced by amoxicillin.
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