ArticleJournal of ophthalmology2018
Total Penetrating Keratoplasty: Indications, Therapeutic Approach, and Long-Term Follow-Up.
Article in Journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Sequential ocular surgeries and multimodal immunosuppression for bilateral, medically refractory seronegative scleritis with severe peripheral corneal stromal thinning: a case report.BMC ophthalmology · 2026Article
- Outcomes of Therapeutic and Tectonic Penetrating Keratoplasty for Advanced Corneal Disease.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Advances in corneal transplantation.Eye (London, England) · 2025Review
- Prevalence of Dry Eye Disease and Ocular Surface Abnormalities in Eyes with Corneal Transplantation: A Cross-Sectional Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Renaissance of an Emerging Pathogen-Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Clinical manifestations and outcomes of HSK following corneal transplantation.Frontiers in medicine · 2025Review
- Age-related analysis of corneal biomechanical parameters in healthy Chinese individuals.Scientific reports · 2024Article
- Application of biomaterials and nanotechnology in corneal tissue engineering.The Journal of international medical research · 2023Review
- Comparison of Robot-Assisted and Manual Cannula Insertion in Simulated Big-Bubble Deep Anterior Lamellar Keratoplasty.Micromachines · 2023Article
- Corneal perforation associated with ocular graft-versus-host disease.Frontiers in oncology · 2022Article
- Article
- Association Between Atopic Keratoconjunctivitis and the Risk of Recurrent Corneal Erosion.Frontiers in medicine · 2021Article
- Indications and Surgical Techniques for Repeat Corneal Transplantation in Eastern China: A Twelve-Year Study.Journal of ophthalmology · 2021Article
- Endothelial cell loss rate after penetrating keratoplasty: optical versus therapeutic grafts.Medical hypothesis, discovery & innovation ophthalmology journal · 2021Article
- Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.Frontiers in medicine · 2021Review
- Amniotic Membrane as a Main Component in Treatments Supporting Healing and Patch Grafts in Corneal Melting and Perforations.Journal of ophthalmology · 2020Article
- Changing trends in penetrating keratoplasty indications at a tertiary eye care center in Budapest, Hungary between 2006 and 2017.International journal of ophthalmology · 2020Article
- Corneal graft melting: a systematic review.International journal of ophthalmology · 2020Review
- Novel dynamic corneal response parameters in a practice use: a critical review.Biomedical engineering online · 2019Review
- Outcome of Sclerokeratoplasty in Devastating Sclerocorneal Infections.Journal of current ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEvaluation of the indications, anatomical and functional results, and complications of total penetrating keratoplasty (TPK) in disorders involving whole cornea. MATERIALS AND
methodsWe analyzed outcomes of the surgical treatment of 47 eyes of 46 patients that underwent TPK. Indications were infectious keratitis, autoimmune disease, injury of the eyeball (mainly chemical burns), and other combined disorders. The surgical technique involved dissection of affected tissues with a margin of 1.0 mm. The size of the corneal graft ranged from 10.0 to 14.0 mm. We analyzed indications, outcomes, and complications of surgery.
resultsFinal restoration of the ocular integrity and maintenance of the globe were achieved in 27 eyes (57%). More than one surgery was necessary in a total of 29 eyes (62%). The frequency of retransplantations did not vary significantly between the groups with different causes of corneal melting/perforation (63% of eyes with infection, 66% of eyes after trauma and 70% of eyes of patients with autoimmune disorders). Surgical treatment failed in 20 eyes (43%). Evisceration was necessary in 13 eyes (28%), phthisis occurred in 7 cases (15%).
conclusionTPK should be considered as a last line treatment in huge corneal destruction to restore integrity of the eye globe.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.