Evidence map›Paper›PMID 29850111›Full record

ArticleJournal of thoracic disease2018

Clinical and molecular characteristics of unicentric mediastinal Castleman disease.

Antoine Legras, Anne Tallet, Audrey Didelot, Aurélie Cazes, Claire Danel, Angela Hin, Raphaël Borie, Bruno Crestani, Yves Castier, Patrick Bagan and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Antoine LegrasDivision of Thoracic Surgery and Lung Transplantation, Georges Pompidou European Hospital, Paris-Descartes University, Sorbonne Paris Cité University, Paris, France.
Anne TalletDivision of Molecular Biology, Georges Pompidou European Hospital, Paris-Descartes University, Sorbonne Paris Cité University, Paris, France.
Audrey DidelotINSERM UMR-S1147, CNRS SNC 5014, Paris-Descartes University, Sorbonne Paris Cité University, Paris, France.
Aurélie CazesDivision of Pathology, Bichat Hospital, Paris-Diderot University, Paris, France.
Claire DanelDivision of Pathology, Bichat Hospital, Paris-Diderot University, Paris, France.
Angela HinINSERM UMR-S1152, Bichat Hospital, Paris-Diderot University, Paris, France.
Raphaël BorieDivision of Pneumology, Bichat Hospital, Paris-Diderot University, Paris, France.
Bruno CrestaniINSERM UMR-S1152, Bichat Hospital, Paris-Diderot University, Paris, France.
Yves CastierINSERM UMR-S1152, Bichat Hospital, Paris-Diderot University, Paris, France.
Patrick BaganDivision of Thoracic Surgery and Lung Transplantation, Georges Pompidou European Hospital, Paris-Descartes University, Sorbonne Paris Cité University, Paris, France.
Françoise Le Pimpec-BarthesDivision of Thoracic Surgery and Lung Transplantation, Georges Pompidou European Hospital, Paris-Descartes University, Sorbonne Paris Cité University, Paris, France.
Marc RiquetDivision of Thoracic Surgery and Lung Transplantation, Georges Pompidou European Hospital, Paris-Descartes University, Sorbonne Paris Cité University, Paris, France.
Hélène BlonsINSERM UMR-S1147, CNRS SNC 5014, Paris-Descartes University, Sorbonne Paris Cité University, Paris, France.
Pierre MordantINSERM UMR-S1152, Bichat Hospital, Paris-Diderot University, Paris, France.
Inserm · FRClinica de Pneumologie Iaşi · ROUniversité Paris Cité · FRCentre Hospitalier Victor Dupouy · FRDélégation Paris 7 · FRHôpital Européen Georges-Pompidou · FRSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnicentric mediastinal Castleman disease (CD) is a rare condition, poorly characterized due to the small number of cases and the absence of genomic study. We analyzed clinical, radiological, histological and genomic patterns associated with mediastinal CD in a substantial case series.

resultsEleven patients were identified (mean age 41±15 years, sex-ratio 0.8, median follow-up 78 months). Surgical approach was thoracotomy (n=6), sternotomy (n=4), and VATS (n=1). Additional procedures included thymectomy in three cases, mediastinal lymphadenectomy in two cases, and bilobectomy in one case. One patient presented local relapse as a follicular dendritic cell sarcoma, leading to death 48 months after the first resection. Within 9 patients whose FFPE blocks were available, 2 mutations were found: VHL (p.F119L, 35%, n=1) and JAK3 (p.V718L, 53%, n=1). Phospho-AKT and phospho-mTOR stainings were negative in all cases, whereas phospho-S6RP staining was positive in eight cases, mainly in interfollicular cell cytoplasm.

conclusionsFrom this series of patients with unicentric mediastinal CD, we observed 2 cases of potential driver mutations and 8 cases of phospho-S6RP activation not related to AKT-mTOR. Larger studies are required to decipher more precisely the molecular abnormalities and potential therapeutic targets underlying this uncommon condition.

Indexed as

Castleman disease (CD)Mediastinal tumormolecular biologytumor biologytumor markers

Identifiers

PMID29850111
PMCPMC5949489
OpenAlexW2799637294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.