ReviewJournal of intensive care2018
Heat stroke.
Review in Journal of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Heatstroke Over the Past Decade: Risk Factors, Long-Term Health Consequences, and Preventive Measures.Journal of general internal medicine · 2026Pooled it
- Epidemiology of Exertional Heat Illness in the Military: A Systematic Review of Observational Studies.International journal of environmental research and public health · 2020Pooled it
- Exertional heat stroke-related acute kidney injury: novel animal and cellular models.Renal failure · 2026Article
- Multiple organ failure following severe heat stroke complicated by AMSAN-type Guillain-Barré syndrome: a case report and literature review.BMC neurology · 2026Review
- Occupational related heat stress exposure and heat-related symptoms among sugarcane workers in Thailand.International archives of occupational and environmental health · 2026Article
- Prevalence and Risk Factors of Heat-Related Illness Among Pilgrims During the Hajj Season 2024: A Cross-Sectional Study.Journal of epidemiology and global health · 2026Article
- Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.JCI insight · 2026Article
- Early seizures and heterogeneity of physiologic recovery in heat-related illness: a nationwide registry study.Critical care (London, England) · 2026Article
- Temperature-Gradient Transcriptomic Atlas Reveals the PPAR Signaling Pathway Dysfunction in Heat Stroke Induced Liver Injury.FASEB bioAdvances · 2026Article
- Extracorporeal Cooling in Heat Stroke Induced Takotsubo Cardiomyopathy.Case reports in critical care · 2026Article
- Lethal Heat and Humidity Events.Annual review of environment and resources · 2025Article
- Machine learning model for early prediction of acute kidney injury in heatstroke patients based on the first 24 h hospitalization data.Scientific reports · 2025Article
- Analyzing cardiovascular disease hospitalization risks due to cold and heat waves in Dezful.Scientific reports · 2025Article
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- Evaluating Heat Stress in Occupational Setting with No Established Safety Standards Using Collective Data from Wearable Biosensors.Sensors (Basel, Switzerland) · 2025Article
- Liver fatty acid-binding protein point-of-care testing detects heat-induced organ damage: a pilot study in Japanese male self-defense force personnel.Scientific reports · 2025Article
- The feasibility of point-of-care testing for initial urinary liver fatty acid-binding protein to estimate severity in severe heatstroke.Scientific reports · 2025Article
- Proposing adjustments to heat safety thresholds for junior high and high school sports clubs in Japan.International journal of biometeorology · 2025Article
- Heatstroke-Induced Inflammatory Response and Therapeutic Biomarkers.Biomedicines · 2025Review
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeat stroke is a life-threatening injury requiring neurocritical care; however, heat stroke has not been completely examined due to several possible reasons, such as no universally accepted definition or classification, and the occurrence of heat wave victims every few years. Thus, in this review, we elucidate the definition/classification, pathophysiology, and prognostic factors related to heat stroke and also summarize the results of current studies regarding the management of heat stroke, including the use of intravascular balloon catheter system, blood purification therapy, continuous electroencephalogram monitoring, and anticoagulation therapy. MAIN BODY: Two systems for the definition/classification of heat stroke are available, namely Bouchama's definition and the Japanese Association for Acute Medicine criteria. According to the detailed analysis of risk factors, prevention strategies for heat stroke, such as air conditioner use, are important. Moreover, hematological, cardiovascular, neurological, and renal dysfunctions on admission are associated with high mortality, which thus represent the potential targets for intensive and specific therapies for patients with heat stroke. No prospective, comparable study has confirmed the efficacy of intravascular cooling devices, anticoagulation, or blood purification in heat stroke.
conclusionThe effectiveness of cooling devices, drugs, and therapies in heat stroke remains inconclusive. Further large studies are required to continue to evaluate these treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.