ReviewOxidative medicine and cellular longevity2018
The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions.
Review in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 284 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
284 citing papers in PubMed, 5 syntheses or guidelines pooled it, 612 citations in OpenAlex.
- Serum levels of trace elements in patients with prostate cancer: a systematic review and meta-analysis.Cancer causes & control : CCC · 2025Pooled it
- Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review.JMIR dermatology · 2024Pooled it
- Association of Blood Manganese and Preeclampsia: A Systematic Review and Meta-analysis.Biological trace element research · 2024Pooled it
- Exploring Gene-Diet Interactions for Mother-Child Health: A Systematic Review of Epidemiological Studies.Nutrients · 2024Pooled it
- The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases.International journal of molecular sciences · 2023Pooled it
- Almond Consumption Improves Inflammatory Profiles Independent of Weight Change: A 6-Week Randomized Controlled Trial in Adults with Obesity.Nutrients · 2026Trial
- Development and Validation of an ICP-MS/MS Method for Multi-elemental Analysis of Human Hair with Application to Heart Failure.Biological trace element research · 2026Article
- Effects of Excessive Manganese Exposure on Testicular Oxidative Stress, Histopathology, and Nrf2 Signaling Pathway in Mice.Biological trace element research · 2026Article
- Selected Trace Elements in Blood of Women with Preeclampsia in Kongo Central, DR Congo.Biological trace element research · 2026Article
- Article
- Association of dietary oxidative balance score, dietary inflammatory potential and fractures among adults aged ≥ 40 years in the United States in 1999-2018.Asia Pacific journal of clinical nutrition · 2026Article
- Persistent effects of pre-differentiation manganese exposure on adipogenesis and metabolic function in differentiated 3T3-L1 adipocyte cells.Journal of hazardous materials advances · 2026Article
- Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence.Environmental science & technology · 2026Article
- Design, Physicochemical Characterization, and Antibacterial Activity of Freeze-Dried Sodium Alginate Sponges Loaded With Amazonian Oil (Carapa guianensis Aubl.) and a Mn(II)-Phenanthroline Complex for Potential Use in Topical Applications.Chemistry & biodiversity · 2026Article
- Association between metal mixture exposure and the risk of POI: a case control study.BMC women's health · 2026Article
- Manganese: biology, physiology and role in disease.Cell discovery · 2026Review
- Selenium biofortification in conditions of soil salinity improve some nutritional value parameters of spinach for the fresh market.Scientific reports · 2026Article
- Comparative nutritional analysis of newly developed interspecific citrus hybrids: multivariate insights for crop improvement.Scientific reports · 2026Article
- Association between blood manganese and cognitive function in a national representative survey.Journal of occupational medicine and toxicology (London, England) · 2026Article
- Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post-Synapses of Neurons and Enhanced Uptake in Astrocytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
224 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manganese (Mn) is an essential element that is involved in the synthesis and activation of many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In addition, Mn is one of the required components for Mn superoxide dismutase (MnSOD) that is mainly responsible for scavenging reactive oxygen species (ROS) in mitochondrial oxidative stress. Both Mn deficiency and intoxication are associated with adverse metabolic and neuropsychiatric effects. Over the past few decades, the prevalence of metabolic diseases, including type 2 diabetes mellitus (T2MD), obesity, insulin resistance, atherosclerosis, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and hepatic steatosis, has increased dramatically. Previous studies have found that ROS generation, oxidative stress, and inflammation are critical for the pathogenesis of metabolic diseases. In addition, deficiency in dietary Mn as well as excessive Mn exposure could increase ROS generation and result in further oxidative stress. However, the relationship between Mn and metabolic diseases is not clear. In this review, we provide insights into the role Mn plays in the prevention and development of metabolic diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.