Evidence map›Paper›PMID 29849909›Full record

ArticleOxidative medicine and cellular longevity2018

Hypermethylation of

Michalina Wezyk, Magdalena Spólnicka, Ewelina Pośpiech, Beata Pepłońska, Renata Zbieć-Piekarska, Jan Ilkowski, Maria Styczyńska, Anna Barczak, Marzena Zboch, Anna Filipek-Gliszczynska and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Epigenetics in Alzheimer's Disease: A Critical Overview.International journal of molecular sciences · 2024
    Review
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  14. Article
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  17. Review
  18. DNA methylation of AHCY may increase the risk of ischemic stroke.Bosnian journal of basic medical sciences · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Michalina WezykLaboratory of Neurogenetics, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre of the Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.ORCID 0000-0001-7498-4610
Magdalena SpólnickaCentral Forensic Laboratory of the Police, 7 Aleje Ujazdowskie Street, 00-583 Warsaw, Poland.
Ewelina PośpiechDepartment of Genetics and Evolution, Institute of Zoology of the Jagiellonian University, 9 Gronostajowa Street, 30-387 Krakow, Poland.
Beata PepłońskaLaboratory of Neurogenetics, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre of the Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Renata Zbieć-PiekarskaCentral Forensic Laboratory of the Police, 7 Aleje Ujazdowskie Street, 00-583 Warsaw, Poland.
Jan IlkowskiFaculty of Health Sciences, Department of Emergency Medicine, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland.
Maria StyczyńskaLaboratory of Neurogenetics, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre of the Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Anna BarczakLaboratory of Neurogenetics, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre of the Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.ORCID 0000-0002-8044-7368
Marzena ZbochCenter of Alzheimer's Disease of Wroclaw Medical University, 12 Jana Pawla II Street, 59-330 Scinawa, Poland.
Anna Filipek-GliszczynskaClinical Department of Neurology, Extrapyramidal Disorders and Alzheimer's Outpatient Clinic, Central Clinical Hospital of the Ministry of Interior in Warsaw, 137 Woloska Street, 02-507 Warsaw, Poland.
Magdalena SkrzypczakLaboratory of Bioinformatics and Systems Biology, Centre of New Technologies, University of Warsaw, 93 Zwirki i Wigury Street, 02-089 Warsaw, Poland.
Krzysztof GinalskiLaboratory of Bioinformatics and Systems Biology, Centre of New Technologies, University of Warsaw, 93 Zwirki i Wigury Street, 02-089 Warsaw, Poland.
Michał KabzaLaboratory of Bioinformatics, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 89 Umultowska Street, 61-614 Poznan, Poland.
Izabela MakałowskaLaboratory of Bioinformatics, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 89 Umultowska Street, 61-614 Poznan, Poland.
Maria Barcikowska-KotowiczLaboratory of Neurogenetics, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre of the Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Wojciech BranickiCentral Forensic Laboratory of the Police, 7 Aleje Ujazdowskie Street, 00-583 Warsaw, Poland.
Cezary ŻekanowskiLaboratory of Neurogenetics, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre of the Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland.
Mossakowski Medical Research Institute, Polish Academy of Sciences · PLCentralne Laboratorium Kryminalistyczne Policji · PLInstitute of Molecular Biology and Biotechnology · BGJagiellonian University · PLUniversity of Warsaw · PLWroclaw Medical University · PLCentral Clinical Hospital · PLPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic mechanisms play an important role in the development and progression of various neurodegenerative diseases. Abnormal methylation of numerous genes responsible for regulation of transcription, DNA replication, and apoptosis has been linked to Alzheimer's disease (AD) pathology. We have recently performed whole transcriptome profiling of familial early-onset Alzheimer's disease (fEOAD) patient-derived fibroblasts. On this basis, we demonstrated a strong dysregulation of cell cycle checkpoints and DNA damage response (DDR) in both fibroblasts and reprogrammed neurons. Here, we show that the aging-correlated hypermethylation of

Indexed as

DNA MethylationSignal TransductionAdultAgedAged, 80 and overAlzheimer DiseaseApoptosisBRCA1 ProteinCell Cycle CheckpointsCheckpoint Kinase 1DNA RepairFemaleFibroblastsGene Regulatory NetworksHumansIntracellular Signaling Peptides and ProteinsBRCA1 ProteinBRCA1 protein, humanCheckpoint Kinase 1Intracellular Signaling Peptides and ProteinsKLF14 protein, humanKLF4 protein, humanKruppel-Like Factor 4Kruppel-Like Transcription FactorsMembrane ProteinsMetalloproteinsSp Transcription FactorsTP53 protein, humanTRIM59 protein, humanTripartite Motif ProteinsTumor Suppressor Protein p53

Identifiers

PMID29849909
PMCPMC5904768
OpenAlexW2796131839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.