Evidence map›Paper›PMID 29849883›Full record

GuidelineOxidative medicine and cellular longevity2018

GRP78 Promotes Neural Stem Cell Antiapoptosis and Survival in Response to Oxygen-Glucose Deprivation (OGD)/Reoxygenation through PI3K/Akt, ERK1/2, and NF-

Qian Liu, Yun Li, Lin Zhou, Yunzi Li, Pengfei Xu, Xiaoyun Liu, Qiushi Lv, Juanji Li, Hongquan Guo, Haodi Cai and 2 more

Open access · hybridAbstract readGuideline
In one paragraph

Guideline in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. A Tale of Two: When Neural Stem Cells Encounter Hypoxia.Cellular and molecular neurobiology · 2023
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Fibrauretine reduces ischemia/reperfusion injury via RISK/eNOS activation.Naunyn-Schmiedeberg's archives of pharmacology · 2020
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Qian LiuDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.ORCID 0000-0002-1937-0568
Yun LiDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.ORCID 0000-0003-1999-7659
Lin ZhouCollege of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing, Jiangsu 210023, China.
Yunzi LiDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.ORCID 0000-0003-0748-4370
Pengfei XuDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.ORCID 0000-0002-1903-138X
Xiaoyun LiuDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.
Qiushi LvDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.
Juanji LiDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.ORCID 0000-0002-1030-9525
Hongquan GuoDepartment of Neurology, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu 210002, China.ORCID 0000-0003-1254-1261
Haodi CaiDepartment of Neurology, Jinling Hospital, Southeast University, Nanjing, Jiangsu 210002, China.ORCID 0000-0001-6685-2036
Rui SunDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.ORCID 0000-0003-0949-4249
Xinfeng LiuDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China.ORCID 0000-0002-8182-9632
Nanjing General Hospital of Nanjing Military Command · CNNanjing Normal University · CNSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When brain injury happens, endogenous neural stem cells (NSCs) located in the adult subventricular zone (SVZ) and subgranular zone (SGZ) are attacked by ischemia/reperfusion to undergo cellular apoptosis and death before being induced to migrate to the lesion point and differentiate into mature neural cells for damaged cell replacement. Although promoting antiapoptosis and NSC survival are critical to neuroregeneration, the mechanism has yet been elucidated clearly. Here in this study, we established an

Indexed as

AnimalsApoptosisCell SurvivalDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPGlucoseHeat-Shock ProteinsMiceNeural Stem CellsOxygenPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTranscription Factor RelATransfectionEndoplasmic Reticulum Chaperone BiPGlucoseHeat-Shock ProteinsHspa5 protein, mouseOxygenPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTranscription Factor RelA

Identifiers

PMID29849883
PMCPMC5914129
OpenAlexW2797046371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.