Evidence map›Paper›PMID 29849874›Full record

ArticleOxidative medicine and cellular longevity2018

Oxidative Stress Induces HSP90 Upregulation on the Surface of Primary Human Endothelial Cells: Role of the Antioxidant 7,8-Dihydroxy-4-methylcoumarin in Preventing HSP90 Exposure to the Immune System.

Elisabetta Profumo, Brigitta Buttari, Lavinia Tinaburri, Daniela D'Arcangelo, Maurizio Sorice, Antonella Capozzi, Tina Garofalo, Antonio Facchiano, Rita Businaro, Prashant Kumar and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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  8. Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing.International journal of molecular sciences · 2022
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  9. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Elisabetta ProfumoDepartment of Cardiovascular, Dysmetabolic and Aging-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0002-7261-8884
Brigitta ButtariDepartment of Cardiovascular, Dysmetabolic and Aging-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0002-0575-4106
Lavinia TinaburriLaboratory of Molecular and Cellular Biology, Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via Monti di Creta 104, 00167 Rome, Italy.
Daniela D'ArcangeloLaboratory of Vascular Pathology, Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via Monti di Creta 104, 00167 Rome, Italy.
Maurizio SoriceDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-3534-1502
Antonella CapozziDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0001-6508-7731
Tina GarofaloDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
Antonio FacchianoLaboratory of Vascular Pathology, Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via Monti di Creta 104, 00167 Rome, Italy.
Rita BusinaroDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Viale XXIV Maggio 7, 04100 Latina, Italy.ORCID 0000-0002-7890-8524
Prashant KumarUniversity of Delhi, Bioorganic Laboratory, Department of Chemistry, New Delhi 110 007, India.
Brajendra K SinghUniversity of Delhi, Bioorganic Laboratory, Department of Chemistry, New Delhi 110 007, India.
Virinder S ParmarUniversity of Delhi, Bioorganic Laboratory, Department of Chemistry, New Delhi 110 007, India.
Luciano SasoDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-4530-8706
Rachele RiganòDepartment of Cardiovascular, Dysmetabolic and Aging-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0003-3014-3523
Sapienza University of Rome · ITIstituto Dermopatico dell'Immacolata · ITIstituto Superiore di Sanità · ITUniversity of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously demonstrated that human heat shock protein 90 (HSP90), an intracellular self protein, is the target of cellular and humoral autoimmune responses in patients with carotid atherosclerosis. In this study, we evaluated

Indexed as

AntioxidantsCoumarinsEndothelial CellsHSP90 Heat-Shock ProteinsHumansOxidative StressUp-Regulation7,8-dihydroxy-4-methylcoumarinAntioxidantsCoumarinsHSP90 Heat-Shock Proteins

Identifiers

PMID29849874
PMCPMC5914108
OpenAlexW2797601104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.