Evidence map›Paper›PMID 29849824›Full record

ArticleDisease markers2018

Cell-Free Circulating Methylated SEPT9 for Noninvasive Diagnosis and Monitoring of Colorectal Cancer.

Bo Fu, Peng Yan, Shan Zhang, Yan Lu, Li Pan, Wenqiang Tang, Shen Chen, Shuangfeng Chen, Anqi Zhang, Wei Liu

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06342440 (A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer), which is not on this map. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06342440 recruitingnot on this mapstarted 2020, after this paper: background citation

A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer

TypeobservationalSponsorCity of Hope Medical CenterRan2020 to 2028Enrolled2,000ConditionsColorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal AdenocarcinomaArmsDENEB
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  4. Diagnostic Value and Clinical Significance of Methylated SEPT9 for Colorectal Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019
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  5. Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review.International journal of molecular sciences · 2018
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bo FuDepartment of Central Laboratory, Liaocheng People's Hospital, Liaocheng, China.
Peng YanDepartment of Gastroenterology, Liaocheng People's Hospital, Liaocheng, China.
Shan ZhangDepartment of Gastroenterology, Liaocheng People's Hospital, Liaocheng, China.
Yan LuDepartment of Gastroenterology, Liaocheng People's Hospital, Liaocheng, China.
Li PanDepartment of Central Laboratory, Liaocheng People's Hospital, Liaocheng, China.
Wenqiang TangDepartment of Central Laboratory, Liaocheng People's Hospital, Liaocheng, China.
Shen ChenDepartment of Breast and Thyroid Surgery, Liaocheng People's Hospital, Liaocheng, China.
Shuangfeng ChenDepartment of Central Laboratory, Liaocheng People's Hospital, Liaocheng, China.
Anqi ZhangDepartment of Central Laboratory, Liaocheng People's Hospital, Liaocheng, China.ORCID 0000-0001-5128-2464
Wei LiuDepartment of Central Laboratory, Liaocheng People's Hospital, Liaocheng, China.ORCID 0000-0001-7138-2913
Liaocheng People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of early-stage tumor and monitoring therapeutic efficacy and recurrence or metastasis of colorectal cancer (CRC) are urgently warranted for improving the outcome of CRC patients and reducing the disease-related mortality. In this study, we evaluated the diagnostic value of cell-free circulating methylated SEPT9 (mSEPT9) for CRC and beyond CRC and examined the potentiality of mSEPT9 in assessing therapeutic efficacy and monitoring recurrence of CRC. Our results confirmed the favorable diagnostic value of plasma mSEPT9 for CRC, with a sensitivity of 61.22% (95% confidence interval (CI): 51.33%-70.27%) and specificity of 93.7% (95% CI: 91.09%-95.57%) using 2/3 algorithm. The positive rate of mSEPT9 in CRC was correlated with tumor size, histological grade, and general histological type (

Indexed as

DNA MethylationAgedBiomarkers, TumorCell-Free Nucleic AcidsColorectal NeoplasmsFemaleHumansMaleMiddle AgedNeoplasm MetastasisSeptinsBiomarkers, TumorCell-Free Nucleic AcidsSEPTIN9 protein, humanSeptins

Identifiers

PMID29849824
PMCPMC5937566
OpenAlexW2799772435

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.