ArticleExperimental and therapeutic medicine2018
Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome.
Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Association between changes in estradiol, serotonin, and BDNF and antidepressant response in perimenopausal depression: a retrospective cohort study comparing integrated TCM-acupuncture with SSRIs.Frontiers in psychiatry · 2026Article
- The non-linear relationship between atherogenic index of plasma and stroke: a study among middle-aged and elderly Chinese adults with depression.Lipids in health and disease · 2025Article
- Antidepressant Activity of Agarwood Essential Oil: A Mechanistic Study on Inflammatory and Neuroprotective Signaling Pathways.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome.Frontiers in molecular biosciences · 2025Article
- Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions.Military Medical Research · 2024Review
- The Role of Estrogen across Multiple Disease Mechanisms.Current issues in molecular biology · 2024Review
- The moderating effect of physical activity on the relationship between neutrophil count and depressive symptoms.Scientific reports · 2024Article
- Understanding the Biological Relationship between Migraine and Depression.Biomolecules · 2024Review
- Menopause-Associated Depression: Impact of Oxidative Stress and Neuroinflammation on the Central Nervous System-A Review.Biomedicines · 2024Review
- Asiaticoside improves depressive-like behavior in mice with chronic unpredictable mild stress through modulation of the gut microbiota.Frontiers in pharmacology · 2024Article
- Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders.Pharmacological reports : PR · 2023Review
- Neuroendocrine pathogenesis of perimenopausal depression.Frontiers in psychiatry · 2023Review
- Exploration of a Brain-Liver-Communication-Related Mechanism Involved in the Experimental Perimenopausal Depression Rat Model using Chaihu-Shugan-San.Neurochemical research · 2022Article
- Neuroprotective Effects of Estrogen Through BDNF-Transient Receptor Potential Channels 6 Signaling Pathway in the Hippocampus in a Rat Model of Perimenopausal Depression.Frontiers in aging neuroscience · 2022Article
- A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Identification of Gene Co-Expression Modules and Core Genes Related to Immune Disorders in Major Depression Disorder.International journal of general medicine · 2021Article
- Article
- Rhynchophylline Attenuates Tourette Syndrome via BDNF/NF-κB Pathway In Vivo and In Vitro.Neurotoxicity research · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship of depression with levels of serum inflammatory factors and brain-derived neurotrophic factor (BDNF) in patients with perimenopausal syndrome was analyzed to investigate the predictive values of risk factors for depression in patients with perimenopausal syndrome. A total of 73 patients with perimenopausal syndrome were selected, and divided into the depression (n=30) and non-depression (n=43) groups. Results showed that the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores in the depression group were significantly higher than those in the non-depression group (P<0.05). The serum BDNF level in the depression group was significantly lower than that in the non-depression group (P<0.05). The levels of serum inflammatory factors, including C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), in depression group were obviously higher than those in non-depression group (P<0.05). The correlation analyses of serum inflammatory factor and BDNF levels with depression showed that CRP and TNF-α were positively correlated with SDS score, while BDNF level was negatively correlated with SDS score. Logistic regression analyses revealed that menstrual status, chronic diseases, serum inflammatory factors (CRP, IL-6 and TNF-α) and BDNF levels had independent predictive values for depression in patients with perimenopausal syndrome (P<0.05). In conclusion, levels of serum CRP, IL-6, TNF-α and BDNF can be used as judgment indicators for the severity of depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.