Evidence map›Paper›PMID 29849627›Full record

ArticleInternational journal of endocrinology2018

Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats.

Maria J Crespo, Marie Roman, Jonathan Matias, Myrna Morales, Hector Torres, Jose Quidgley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maria J CrespoDepartment of Physiology, University of Puerto Rico-School of Medicine, San Juan, PR, USA.ORCID 0000-0001-7017-7328
Marie RomanDepartment of Physiology, University of Puerto Rico-School of Medicine, San Juan, PR, USA.
Jonathan MatiasDepartment of Anesthesiology, University of Puerto Rico-School of Medicine, San Juan, PR, USA.
Myrna MoralesDepartment of Anesthesiology, University of Puerto Rico-School of Medicine, San Juan, PR, USA.
Hector TorresDepartment of Anesthesiology, University of Puerto Rico-School of Medicine, San Juan, PR, USA.ORCID 0000-0002-2886-5386
Jose QuidgleyDepartment of Physiology, University of Puerto Rico-School of Medicine, San Juan, PR, USA.
University of Puerto Rico System · PR

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Carmen M Velez Vega · 2017 to 2026
$35.8M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
NIGMS NIH HHS R25 GM061838NIMHD NIH HHS G12 MD007600NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

Diabetics have a higher risk of developing cerebral vasospasms (CVSP) than nondiabetics. The addition of the ryanodine receptor (RyR) blocker dantrolene to standard therapies reduces vasospasms in nondiabetics. Whether diabetics with CVSP also benefit from this drug, however, is unknown. We evaluated the effects of a 30 min incubation with dantrolene (50

Identifiers

PMID29849627
PMCPMC5933070
OpenAlexW2799571534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.