Evidence map›Paper›PMID 29849621›Full record

ArticleInternational journal of endocrinology2018

Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study.

M Thomas, D Beckers, C Brachet, H Dotremont, M-C Lebrethon, P Lysy, G Massa, N Reynaert, R Rooman, S van der Straaten and 2 more

Abstract read
In one paragraph

Article in International journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M ThomasThe Belgian Society for Pediatric Endocrinology and Diabetology (BESPEED), Bruxelles, Belgium.
D BeckersDivision of Pediatric Endocrinology, Université catholique de Louvain, CHU UCL Namur, Yvoir, Belgium.
C BrachetDivision of Pediatric Endocrinology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Bruxelles, Belgium.
H DotremontDivision of Pediatric Endocrinology, UZ Antwerpen, Antwerpen, Belgium.
M-C LebrethonDivision of Pediatric Endocrinology, CHU-Notre-Dame des Bruyères, Chênée, Belgium.
P LysyDivision of Pediatric Endocrinology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.ORCID 0000-0003-1598-7998
G MassaDivision of Pediatric Endocrinology, Jessa Ziekenhuis, Hasselt, Belgium.
N ReynaertDivision of Pediatric Endocrinology, UZ Leuven, Leuven, Belgium.
R RoomanThe Belgian Society for Pediatric Endocrinology and Diabetology (BESPEED), Bruxelles, Belgium.
S van der StraatenDivision of Pediatric Endocrinology, UZ Gent, Gent, Belgium.
M RoelantsDepartment of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
J De SchepperDivision of Pediatric Endocrinology, UZ Brussel, Brussel, Belgium.ORCID 0000-0002-2999-0250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInformation on the efficacy of GH treatment in short SGA children starting their treatment in adolescence is limited. Therefore, adult height (AH), total height gain, and pubertal height gain were evaluated in short SGA children who started GH treatment at pubertal onset. PATIENT AND

methodsGrowth data of 47 short SGA adolescents (22 boys) who started GH treatment at pubertal onset (PUB group) were compared with results from 27 short SGA patients (11 boys) who started GH therapy at least 1 year before pubertal onset (PrePUB group).

resultsThe PUB group achieved a mean (±SD) total height gain of 0.8 ± 0.7 SDS and an AH of -2.5 ± 0.7 SDS after 4.1 ± 1.1 years of GH treatment with a dosage of 41.8 ± 8.4

conclusionsShort SGA adolescents starting GH therapy at an early pubertal stage have a modest and variable height gain. A normal AH can be expected in one third of the patients, especially in those with a smaller height deficit at onset of GH treatment.

Identifiers

PMID29849621
PMCPMC5903317

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.