Evidence map›Paper›PMID 29849502›Full record

ArticleMediators of inflammation2018

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-

Yueh-Lun Lee, Che-Jen Hsiao, Fan-Li Lin, Jing-Shiun Jan, Yung-Chen Chou, Yen-Yu Lin, Chih-Kuang Chen, Kwok-Keung Lam, George Hsiao

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yueh-Lun LeeDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-8667-1408
Che-Jen HsiaoLaboratory of Neural Repair, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Fan-Li LinGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Jing-Shiun JanGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yung-Chen ChouGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yen-Yu LinGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chih-Kuang ChenGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Kwok-Keung LamGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
George HsiaoGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0001-9079-3646
Taipei Medical University · TWChang Gung Memorial Hospital · TWChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Much evidence has indicated that matrix metalloproteinases (MMPs) participate in the progression of neuroinflammatory disorders. The present study was undertaken to investigate the inhibitory effect and mechanism of the antipsychotic haloperidol on MMP activation in the stimulated THP-1 monocytic cells. Haloperidol exerted a strong inhibition on tumor necrosis factor- (TNF-)

Indexed as

AnimalsCell SurvivalChromatin ImmunoprecipitationHaloperidolHumansI-kappa B ProteinsLipopolysaccharidesMatrix Metalloproteinase 9MiceMice, Inbred C57BLNF-kappa BSignal TransductionHaloperidolI-kappa B ProteinsLipopolysaccharidesMatrix Metalloproteinase 9NF-kappa B

Identifiers

PMID29849502
PMCPMC5925083
OpenAlexW2797896889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.