Evidence map›Paper›PMID 29849487›Full record

Trial reportMediators of inflammation2018

Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy.

M Ernberg, N Christidis, B Ghafouri, I Bileviciute-Ljungar, M Löfgren, J Bjersing, A Palstam, A Larsson, K Mannerkorpi, B Gerdle and 1 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01226784 (The Effects of Training and Relaxation on Fibromyalgia.), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01226784 nacompletednot on this map

The Effects of Training and Relaxation on Fibromyalgia.

TypeinterventionalSponsorKarolinska InstitutetRan2010 to 2020Enrolled240ConditionsFibromyalgiaArmsPhyscial activity
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  7. [Effects of exercise interventions on anxiety and depressive symptoms in patients with fibromyalgia syndrome: a meta-analysis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

M ErnbergDepartment of Dental Medicine, Karolinska Institutet and Scandinavian Center for Orofacial Neurosciences (SCON), 141 04 Huddinge, Sweden.ORCID 0000-0003-4152-5439
N ChristidisDepartment of Dental Medicine, Karolinska Institutet and Scandinavian Center for Orofacial Neurosciences (SCON), 141 04 Huddinge, Sweden.
B GhafouriPain and Rehabilitation Centre and Department of Medical and Health Sciences, Linköping University, 581 85 Linköping, Sweden.
I Bileviciute-LjungarDepartment of Clinical Sciences, Karolinska Institutet and Department of Rehabilitation Medicine, Danderyd Hospital, 182 88 Stockholm, Sweden.
M LöfgrenDepartment of Clinical Sciences, Karolinska Institutet and Department of Rehabilitation Medicine, Danderyd Hospital, 182 88 Stockholm, Sweden.
J BjersingDepartment of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, Sweden.
A PalstamInstitute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, Sweden.
A LarssonInstitute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, Sweden.
K MannerkorpiInstitute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, Sweden.
B GerdlePain and Rehabilitation Centre and Department of Medical and Health Sciences, Linköping University, 581 85 Linköping, Sweden.
E KosekDepartment of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
Karolinska Institutet · SEUniversity of Gothenburg · SELinköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aims of this study were to compare circulating cytokines between FM and healthy controls and to investigate the effect on cytokine levels by 15 weeks of progressive resistance exercise or relaxation therapy in FM. Baseline plasma cytokine levels and clinical data were analyzed in 125 women with FM and 130 age-matched healthy women. The FM women were then randomized to progressive resistance exercise (

Indexed as

AdultCytokinesExerciseFemaleFibromyalgiaHumansInflammationInterleukin-17Interleukin-1betaInterleukin-2Interleukin-4Interleukin-6Interleukin-8Middle AgedRelaxation TherapyResistance TrainingCytokinesInterleukin-17Interleukin-1betaInterleukin-2Interleukin-4Interleukin-6Interleukin-8Tumor Necrosis Factor-alpha

Identifiers

PMID29849487
PMCPMC5932448
OpenAlexW2801120695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.