Evidence map›Paper›PMID 29849484›Full record

ReviewMediators of inflammation2018

Wound Healing and Omega-6 Fatty Acids: From Inflammation to Repair.

Jéssica R Silva, Beatriz Burger, Carolina M C Kühl, Thamiris Candreva, Mariah B P Dos Anjos, Hosana G Rodrigues

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04186377 (A Study of the Effectiveness of Local S26E Extract Application for Diabetic Foot Ulcer Healing), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04186377 phase2terminatednot on this mapstarted 2020, after this paper: background citation

A Study of the Effectiveness of Local S26E Extract Application for Diabetic Foot Ulcer Healing

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2020 to 2021Enrolled5ConditionsDiabetic Foot, Neuropathic Foot Ulcer, Chronic Diabetic Ulcer of Left Foot (Diagnosis), Chronic Diabetic Foot Ulcer of Right FootArmsStandard-of-care for neuropathic/neuroischemic diabetic foot ulcers, S26E
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Molecules (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Role of Linoleic Acid in Skin and Hair Health: A Review.International journal of molecular sciences · 2024
    Review
  17. Review
  18. Cutaneous Wound Healing and the Effects of Cannabidiol.International journal of molecular sciences · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jéssica R SilvaLaboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Beatriz BurgerLaboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Carolina M C KühlLaboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Thamiris CandrevaLaboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Mariah B P Dos AnjosLaboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Hosana G RodriguesLaboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, SP, Brazil.ORCID 0000-0002-6122-0379
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is an evolutionarily conserved process that is essential for species survival. Wound healing involves a series of biochemical and cellular events that are tightly controlled, divided into 3 concomitant and overlapping phases: inflammation, proliferation, and remodelling. Poor wound healing or a chronic wound represents a silent epidemic that affects billions of people worldwide. Considering the involvement of immune cells in its resolution, recent studies are focused on investigating the roles of immune nutrients such as amino acids, minerals, and fatty acids on wound healing. Among the fatty acids, much attention has been given to omega-6 (

Indexed as

AnimalsCell ProliferationFatty Acids, Omega-6HumansInflammationWound HealingFatty Acids, Omega-6

Identifiers

PMID29849484
PMCPMC5925018
OpenAlexW2796749675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.