Evidence map›Paper›PMID 29849467›Full record

ArticleCancer management and research2018

Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma.

Dawei Chen, Chenyue Zhang, Jiamao Lin, Xinyu Song, Haiyong Wang

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Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

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38citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  15. Emerging roles of circular RNAs in liver cancer.JHEP reports : innovation in hepatology · 2022
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Dawei Chen *Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University.
Chenyue Zhang *Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai.
Jiamao LinDepartment of Internal Medicine-Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Xinyu SongSchool of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan.
Haiyong WangDepartment of Internal Medicine-Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of this study was to analyze the diagnostic and prognostic values of the circular RNA (circRNA) hsa_circ_0128298 in hepatocellular carcinoma (HCC). PATIENTS AND

methodsThe global circRNA expression was measured using circRNA microarray using three pairs of cancer and noncancerous tissues from HCC patients. The microarray analysis revealed that two circRNAs were differentially expressed in the three pairs of cancerous and noncancerous tissues. The higher levels of two representative circRNAs, such as hsa_circ_0128298 and hsa_circ_0091582, were further confirmed by real-time polymerase chain reaction. In addition, the association between the expression level of hsa_circ_0128298 and the clinicopathological features of patients with HCC was further analyzed. The clinical diagnosis value was confirmed by receiver operating characteristic (ROC) curve analysis. Independent prognostic factors of patient outcome were identified using the Cox regression model. The survival data were analyzed by the Kaplan-Meier method, and the differences were evaluated using log-rank tests. Two-sided

resultsThe expression levels of hsa_circ_0128298 in HCC were significantly higher than those of paratumorous tissues (

conclusionhsa_circ_0128298 may promote proliferation and metastasis and potentially represents a novel diagnostic and prognostic biomarker for HCC patients. However, studies with larger sample size are needed to confirm our conclusion.

Indexed as

biomarkercircular RNAdiagnosishepatocellular carcinomahsa_circ_0128298prognosis

Identifiers

PMID29849467
PMCPMC5965387

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