Evidence map›Paper›PMID 29849448›Full record

ArticleAnnals of neurosciences2018

1-Methyl-4-Phenylpyridinium-Induced Death of Differentiated SH-SY5Y Neurons Is Potentiated by Cholesterol.

Anu Raju, Parasuram Jaisankar, Anupom Borah, Kochupurackal Parameswarannayar Mohanakumar

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Implication of Oxysterols and Phytosterols in Aging and Human Diseases.Advances in experimental medicine and biology · 2024
    Review
  4. Review
  5. Article
  6. Review
  7. Ferulic Acid Ameliorates MPPMolecular neurobiology · 2020
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Anu RajuDivision of Cell Biology and Physiology, Kolkata, India.
Parasuram JaisankarDivision of Chemistry, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.
Anupom BorahCellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, India.
Kochupurackal Parameswarannayar MohanakumarDivision of Cell Biology and Physiology, Kolkata, India.
Indian Institute of Chemical Biology · INAcademy of Scientific and Innovative Research · INAssam University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsHypercholesterolemia is recently considered a risk factor for Parkinson's disease (PD), the most consistent neurodegenerative movement disorder. The study aimed to investigate the effect of exogenous cholesterol on 1-methyl-4-phenylpyridinium (MPP

methodsCholesterol (50 μM) when added in the culture media alone or in combination with MPP

resultsCholesterol treatment potentiated a reduction of neuronal viability with loss of TH-positive neurons in cultures. MPP

conclusionApparently, changes in neuronal cholesterol content significantly influenced the neurotoxicity and the direct mitochondrial mechanisms involved in MPP

Indexed as

Cell viabilityCholesterol-induced neuronal deathDopaminergic neuronsMitochondrial membrane potentialTyrosine hydroxylase

Identifiers

PMID29849448
PMCPMC5969353
OpenAlexW2766789771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.