ArticleNeurology. Clinical practice2017
EEG correlates of seizure freedom in genetic generalized epilepsies.
Article in Neurology. Clinical practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 31 citations in OpenAlex.
- Prognostic value of interictal epileptiform discharges on routine EEG in adults with epilepsy.Epilepsia · 2025Article
- Assessing the Need for Repeat EEG in Pediatric Patients with Idiopathic Generalized Epilepsy After Anti-Seizure Medication Withdrawal Following Seizure Freedom.Journal of child neurology · 2025Article
- Generalized spike-waves in idiopathic generalized epilepsies: Does their frequency matter?Brain and behavior · 2024Article
- Machine-learning for the prediction of one-year seizure recurrence based on routine electroencephalography.Scientific reports · 2023Article
- EEG Markers of Treatment Resistance in Idiopathic Generalized Epilepsy: From Standard EEG Findings to Advanced Signal Analysis.Biomedicines · 2022Review
- Prolonged epileptic discharges predict seizure recurrence in JME: Insights from prolonged ambulatory EEG.Epilepsia · 2021Article
- Tablet-based electroencephalography diagnostics for patients with epilepsy in the West African Republic of Guinea.European journal of neurology · 2020Article
- Predictors of Outcome in Juvenile Myoclonic Epilepsy.Risk management and healthcare policy · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated the association between epileptiform EEG abnormalities and the preceding duration of seizure freedom in genetic generalized epilepsies (GGE).
methodsWe analyzed 24-hour ambulatory EEG recordings of patients with GGE diagnosed and classified according to the International League Against Epilepsy criteria. We quantified epileptiform EEG abnormalities into density scores (total duration of epileptiform discharges per hour) and estimated the preceding seizure-free duration at the time of EEG recording based on the last self-reported seizure. We then employed regression analysis to quantitate the relationship between the duration of seizure freedom and EEG variables.
resultsWe analyzed 6,923 epileptiform discharges from 105 patients with abnormal 24-hour EEGs. In the regression analysis exploring the crude associations, we found significant correlations between 6 EEG variables and the duration of seizure freedom indicating that shorter duration of seizure freedom was associated with higher spike densities and longer paroxysms. These associations were not affected by confounders such as syndrome, age at EEG, age at epilepsy onset, sex, duration of epilepsy, or number of antiepileptic drugs.
conclusionsHigher densities and longer durations of epileptiform discharges may be retrospectively associated with a shorter duration of self-reported seizure freedom. Hence, EEG can potentially be used as a biomarker of prognosis in GGE. These findings need to be validated in a prospective study in order to define EEG markers of future seizure freedom.
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