ArticleNature2018
Hippo/Mst signalling couples metabolic state and immune function of CD8α
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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132citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
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Who cites it
132 citing papers in PubMed, 222 citations in OpenAlex.
- Genomic Subtype Influences BH3 Mimetic Drug Sensitivity and Synergy with Cytotoxic Chemotherapeutics in T-cell Acute Lymphoblastic Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Protein phosphatase 2A regulates senescence and immunogenicity in medulloblastoma models.The Journal of clinical investigation · 2026Article
- ITGB5 promotes immune escape in hepatocellular carcinoma by regulating PD-L1 through SETDB1/Hippo signaling pathway.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells.Cell metabolism · 2026Article
- A plant vesicle-dendritic cell chimera for enhancing cancer immunotherapy.Nature communications · 2026Article
- Network-based analysis reveals potential microRNA regulation of oncogenic pathways in SOX10-depleted uveal melanoma.Cellular and molecular life sciences : CMLS · 2026Article
- Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity.Science (New York, N.Y.) · 2026Article
- Defining PI3K Signaling as a Key Regulator of Molecular Heterogeneity and Inflammation in Glomerular Lupus Nephritis.Immune network · 2026Article
- Aberrant long-chain fatty acids metabolism and its interplay with immuno-inflammatory responses in relapsing-remitting multiple sclerosis.Frontiers in immunology · 2026Article
- Single cell transcriptomics reveals dendritic cell subsets in bovine afferent lymph and immune cell-resolved responses to BCG vaccination.Frontiers in immunology · 2026Article
- Role of trained immunity in DCs and macrophages in the induction of Th2 responses and allergy treatment. What do we know?Frontiers in immunology · 2026Review
- EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non-Small Cell Lung Cancer via Hippo Pathway Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Decoding immunometabolism with next-generation tools: lessons from dendritic cells and T cells.The EMBO journal · 2025Review
- NDR2 Kinase Regulates Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity.International journal of molecular sciences · 2025Article
- Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells.Science immunology · 2025Article
- The multifaceted role of YAP in the tumor microenvironment and its therapeutic implications in cancer.Experimental & molecular medicine · 2025Review
- Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells.Science advances · 2025Article
- Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications.Molecular biomedicine · 2025Review
- Hippo pathway and NLRP3-driven NETosis in macrophages: Mechanisms of viral pneumoniaaggravation.Cell death discovery · 2025Article
- The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications.Signal transduction and targeted therapy · 2025Review
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Xingrong DuDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Jing WenDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Yanyan WangDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Peer W F KarmausDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Alireza KhatamianDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Haiyan TanDepartments of Structural Biology and Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Yuxin LiDepartments of Structural Biology and Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Cliff GuyDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Thanh-Long M NguyenDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Yogesh DhunganaDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Geoffrey NealeHartwell Center for Bioinformatics and Biotechnology, St Jude Children's Research Hospital, Memphis, TN, USA.
Junmin PengDepartments of Structural Biology and Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Jiyang YuDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA. jiyang.yu@stjude.org.
Hongbo ChiDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA. hongbo.chi@stjude.org.
St. Jude Children's Research Hospital · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MThe MKP-1/p38 axis: coordinating innate and adaptive immunityR01NS064599 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2008 to 2018
$3.7MMetabolic checkpoint in dendritic cell subsets and adaptive immunityR37AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.6MMulti-level Integrative Proteomics to Alzheimer's Disease PathwaysR01AG053987 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2016 to 2020
$2.2MMetabolic checkpoint in TH17 cell differentiationR01AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$2.2MmTOR signaling in T cell quiescenceR01AI101407 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2013 to 2017
$2.2MTsc1/mTOR axis in immune homeostasis and tumorigenesisR01CA176624 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$1.9MRNA splicing dysfunction in Alzheimer's diseaseR01AG047928 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2015 to 2019
$1.8MMetabolic reprogramming of Tregs in tumor immunityR01CA221290 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2017 to 2020
$1.6MNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA176624NCI NIH HHS R01 CA221290NIAID NIH HHS R01 AI101407NIAID NIH HHS R01 AI105887NIAID NIH HHS R37 AI105887NIA NIH HHS R01 AG047928NIA NIH HHS R01 AG053987NIH HHS AG047928NIH HHS AI101407NIH HHS AI105887NIH HHS CA176624NIH HHS CA221290NIH HHS NS064599NINDS NIH HHS R01 NS064599
Abstract
Dendritic cells orchestrate the crosstalk between innate and adaptive immunity. CD8α
Indexed as
Signal TransductionAlgorithmsAnimalsCD8 AntigensCD8-Positive T-LymphocytesCross-PrimingDendritic CellsHippo KinasesHippo Signaling PathwayHomeostasisInterleukin-12MiceMice, Inbred C57BLNF-kappa BProtein Serine-Threonine KinasesSerine-Threonine Kinase 3CD8alpha antigenCD8 AntigensHippo KinasesInterleukin-12Lats1 protein, mouseLATS2 protein, mouseNF-kappa BProtein Serine-Threonine KinasesSerine-Threonine Kinase 3Stk3 protein, mouseStk4 protein, mouseTumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.