ArticleNature2018
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 394 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
394citing papers in PubMed, 2 pooled it
46.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
394 citing papers in PubMed, 2 syntheses or guidelines pooled it, 625 citations in OpenAlex.
- Targeting p53 pathways: mechanisms, structures, and advances in therapy.Signal transduction and targeted therapy · 2023Pooled it
- Knowledge mapping of autophagy in osteoarthritis from 2004 to 2022: A bibliometric analysis.Frontiers in immunology · 2023Pooled it
- Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells.Nature aging · 2026Article
- The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026Review
- Phytochemical-Based Therapeutic Strategies for Sarcopenia: From Molecular Mechanisms to Clinical Translation.Pharmaceuticals (Basel, Switzerland) · 2026Review
- AMC-F1 regulates mitochondria-autophagy crosstalk independent of nutrient stress.Nature communications · 2026Article
- Insights into the therapeutic strategies for aging and aging-associated diseases.Signal transduction and targeted therapy · 2026Review
- Bat-Inspired Longevity: Immune Damage Management and Nutritional Modulation for Healthy Aging.International journal of molecular sciences · 2026Review
- Longevity Factor Klotho and Resistance to Cognitive Deficits in Individuals with Parkinson's Disease and in an α-Synuclein Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology.Nature aging · 2026Article
- Review
- Autophagy-Independent Function of ATG-18 Is Essential for Gonadal Longevity in Caenorhabditis elegans.Aging cell · 2026Article
- S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1.Nature communications · 2026Article
- Synaptic aging and neurodegeneration: the role of synaptic vesicle dynamics and neurotransmitter imbalance.Biogerontology · 2026Review
- MaR1 and NGF combine to inhibit autophagy through the GSK-3β/β-catenin pathway to promote sciatic nerve repair.Journal of translational medicine · 2026Article
- Positive Feedback Loop of Histone Lactylation-Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- BCL-2 and BCL-xL in Cancer: Regulation, Function, and Therapeutic Targeting.International journal of molecular sciences · 2026Review
- Of Barriers and Loops-How Evolution Limits Most Cancer Risks to Older Ages.Cancer discovery · 2026Review
- Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification.Scientific reports · 2026Article
- Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression.Journal of neuroinflammation · 2026Article
334 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
16 authors at 5 institutions in 1 country.
Álvaro F FernándezCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Salwa SebtiCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yongjie WeiCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zhongju ZouCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mingjun ShiCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kathryn L McMillanCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Congcong HeDepartment of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Tabitha TingCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yang LiuCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wei-Chung ChiangCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Denise K MarcianoDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gabriele G SchiattarellaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Govind BhagatDepartment of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
Orson W MoeDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ming Chang HuDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. ming-chang.hu@utsouthwestern.edu.
Beth LevineCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA. beth.levine@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · USNewYork–Presbyterian Hospital · USNorthwestern University · USSouthwestern Medical Center · US
Funding
Genetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI VIRGIN, HERBERT W · 2014 to 2018
$32.7MKlotho: Therapeutic Agent for Ischemia Reperfusion Induced Acute Kidney InjuryR01DK092461 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HU, MING-CHANG · 2011 to 2021
$3.7MMechanism of Autophagy Activation in the Prevention of Type 2 DiabetesR01DK113170 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HE, CONGCONG · 2017 to 2025
$3.6MKlotho and Phosphate in Chronic Kidney Disease: Pathogenesis and TherapeuticsR01DK091392 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HU, MING-CHANG, MOE, ORSON W · 2011 to 2021
$3.2MBeclin 1-Bcl-2 Interactions: Effects on AutophagyR01CA109618 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI LEVINE, BETH C · 2004 to 2014
$3.1MA novel autophagy gene beclin 2 in the prevention of type 2 diabetes and obesityR00DK094980 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HE, CONGCONG · 2014 to 2016
$728kNCI NIH HHS R01 CA109618NIAID NIH HHS U19 AI109725NIDDK NIH HHS R00 DK094980NIDDK NIH HHS R01 DK091392NIDDK NIH HHS R01 DK092461NIDDK NIH HHS R01 DK113170
Abstract
Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established
Indexed as
AgingAnimalsAutophagosomesAutophagyBeclin-1Cells, CulturedFemaleFibroblastsGene Knock-In TechniquesGlucuronidaseHealthHeLa CellsHumansKlotho ProteinsLongevityMaleBeclin-1GlucuronidaseKlotho ProteinsProto-Oncogene Proteins c-bcl-2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.