ArticleScientific reports2018
Furan-Site Bromination and Transformations of Fraxinellone as Insecticidal Agents Against Mythimna separata Walker.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Leveraging Lewis acid catalysis for cascade construction of multisubstituted furans from active methylenes and 3-oxetanone.Communications chemistry · 2026Article
- Coumarin-1,2,4-Triazole hybrids as potential agents against Brassicogethes aeneus (Fabricius 1775).Scientific reports · 2026Article
- Integrated transcriptome, metabolome and activity-guided fractionation of Parnassia wightiana Wall. reveal its insecticidal potential.BMC plant biology · 2025Article
- Structural Features of Coumarin-1,2,4-Triazole Hybrids Important for Insecticidal Effects AgainstMolecules (Basel, Switzerland) · 2025Article
- Semi-Synthesis of C-Ring Cyclopropyl Analogues of Fraxinellone and Their Insecticidal Activity AgainstMolecules (Basel, Switzerland) · 2020Article
- Article
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Authors and funding
10 authors.
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Abstract
Furan ring of limoninoids is critical in exhibiting insecticidal activity. Herein, fraxinellone (1) was used as a template of furan-containing natural products and a series of its derivatives was synthesized by selective bromination in good yields on gram-scale and following Suzuki-Miyaura or Sonogashira coupling reactions in moderate to good yields. Bromination of limonin (9) was also accomplished without altering other functional groups in high yield. Furthermore, an evaluation of insecticidal activity against the instar larvae of Mythimna separata showed that derivatives 2, 3b, 3g, 5a, 5d and 5h displayed more potent insecticidal activity than 1 and toosendanin.
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