Evidence map›Paper›PMID 29849122›Full record

ArticleOncogene2018

Heterozygous IDH1

Shuang Wei, Jie Wang, Olutobi Oyinlade, Ding Ma, Shuyan Wang, Lisa Kratz, Bachchu Lal, Qingfu Xu, Senquan Liu, Sagar R Shah and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Shuang WeiDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, 430030, Wuhan, China.
Jie WangDepartment of Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Olutobi OyinladeHugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, 21205, USA.
Ding MaHugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, 21205, USA.
Shuyan WangHugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, 21205, USA.
Lisa KratzHugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, 21205, USA.
Bachchu LalHugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-5936-0276
Qingfu XuHugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, 21205, USA.
Senquan LiuDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Sagar R ShahDepartment of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, 32224, USA.
Hao ZhangDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Yunqing LiHugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, 21205, USA.
Alfredo Quiñones-HinojosaDepartment of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, 32224, USA.
Heng ZhuDepartment of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-8426-2889
Zhi-Yong HuangDepartment of General Surgery, Tongji Hospital, Huazhong University of Science and Technology, 430030, Wuhan, China.
Linzhao ChengDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Jiang QianDepartment of Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Shuli XiaHugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, 21205, USA. xia@kennedykrieger.org.
Kennedy Krieger Institute · USJohns Hopkins University · USMayo Clinic in Florida · USTongji Hospital · CN

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Methyl-CpG-dependent transcription factor function in human gliomaR01NS091165 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XIA, SHULI · 2015 to 2019
$1.8M
Differential Regulatory Networks in Disease: Application to Macular DegenerationR01EY024580 · NEI · JOHNS HOPKINS UNIVERSITY · PI QIAN, JIANG · 2014 to 2017
$1.6M
Epigenetics-mediated transcription regulation in mammalsR01GM111514 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI QIAN, JIANG, ZHOU, FENGQUAN · 2014 to 2017
$1.4M
Computational Analysis of Retinal Regulatory Interactions: structure and dynamicsR01EY017589 · NEI · JOHNS HOPKINS UNIVERSITY · PI QIAN, JIANG · 2007 to 2010
$1.1M
Integrative Analyses of Eye Disease Using Genetic and Epigenetic DatasetsR01EY023188 · NEI · JOHNS HOPKINS UNIVERSITY · PI MERBS, SHANNATH L, QIAN, JIANG · 2014 to 2016
$1.1M
NEI NIH HHS R01 EY017589NEI NIH HHS R01 EY023188NEI NIH HHS R01 EY024580NIGMS NIH HHS R01 GM111514NIGMS NIH HHS T32 GM007445NIH HHS EY023188NIH HHS EY024580NIH HHS GM111514NIH HHS R01NS091165NIH HHS T32 GM007445NINDS NIH HHS R01 NS091165
6 · The paper itself

Abstract

Mutations in the isocitrate dehydrogenase 1 (IDH1) gene have been identified in a number of cancer types, including brain cancer. The Cancer Genome Atlas project has revealed that IDH1 mutations occur in 70-80% of grade II and grade III gliomas. Until recently, most of the functional studies of IDH1 mutations in cellular models have been conducted in overexpression systems with the IDH1 wild type background. In this study, we employed a modified CRISPR/Cas9 genome editing technique called "single base editing", and efficiently introduced heterozygous IDH1 R132H mutation (IDH1

Indexed as

HeterozygoteMutationAdaptor Proteins, Signal TransducingAstrocytesCell MovementCell ProliferationDown-RegulationEpigenesis, GeneticHumansIsocitrate DehydrogenasePhosphoproteinsTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingIDH1 protein, humanIsocitrate DehydrogenasePhosphoproteinsTranscription FactorsYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID29849122
PMCPMC6590918
OpenAlexW2807073094

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.