Evidence map›Paper›PMID 29849078›Full record

ArticleScientific reports2018

The Relationship between Cerebral White Matter Integrity and Cognitive Function in Mild Stroke with Basal Ganglia Region Infarcts.

Li-Jun Zuo, Zi-Xiao Li, Rong-Yan Zhu, Yao-Jing Chen, YanHong Dong, Yi-Long Wang, Xing-Quan Zhao, Zhan-Jun Zhang, Perminder Sachdev, Wei Zhang and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Li-Jun ZuoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Zi-Xiao LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Rong-Yan ZhuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Yao-Jing ChenState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, P.R. China.
YanHong DongDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore.
Yi-Long WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Xing-Quan ZhaoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.ORCID 0000-0001-8345-5147
Zhan-Jun ZhangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, P.R. China.
Perminder SachdevCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-9595-3220
Wei ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Yong-Jun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. yongjunwang1962@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild stroke is a known risk factor for dementia. The relationship between cerebral white matter (WM) integrity and cognitive impairment (CI) in mild stroke patients with basal ganglia region infarcts is unknown. Total of 33 stroke patients and 19 age-matched controls underwent diffusion tensor imaging scans and a formal neuropsychological test battery. CI was defined as having a performance score 1.5 SD below the established norm. We compared the differences in Z-scores and Fraction Anisotropy (FA) values among controls, stroke with no CI (NCI) and stroke with CI groups. Multiple linear regressions were performed between FA values in affected regions and neuropsychological tests in stroke patients. The majority of stroke patients were in their 50s (56.90 ± 9.23 years). CI patients exhibited a significantly decreased Z score in visual delayed memory and remarkably decreased FA values in the right external capsule and right fornix (FWE-corrected) compared with NCI patients and controls. In stroke patients, the FA value in the right fornix was positively correlated with delayed visual memory. Mild stroke with basal ganglia region infarcts may be related to widespread abnormality of WM integrity. The lower WM integrity in the right fornix may be a marker of impaired delayed visual memory.

Indexed as

CognitionBasal GangliaCerebral InfarctionFemaleHumansMaleMiddle AgedNeuropsychological TestsWhite Matter

Identifiers

PMID29849078
PMCPMC5976674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.