Evidence map›Paper›PMID 29849051›Full record

ArticleScientific reports2018

Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation.

L Engelbrechtsen, D Gybel-Brask, Y Mahendran, M Crusell, T H Hansen, T M Schnurr, E Hogdall, L Skibsted, T Hansen, H Vestergaard

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

L EngelbrechtsenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0666-0830
D Gybel-BraskDepartment of Gynecology and Obstetrics, Section of Fetal Medicine, Roskilde University Hospital, Roskilde, Denmark.
Y MahendranNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark.
M CrusellNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark.
T H HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5948-8993
T M SchnurrNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6573-4959
E HogdallMolecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
L SkibstedDepartment of Gynecology and Obstetrics, Section of Fetal Medicine, Roskilde University Hospital, Roskilde, Denmark.
T HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
H VestergaardNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark. Henrik.vestergaard@sund.ku.dk.ORCID 0000-0003-3090-269X
University of Copenhagen · DKRoskilde University · DKSteno Diabetes Centers · DK

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

Fetal intrauterine growth is influenced by complex interactions between the maternal genes, environment and fetal genes. The aim of this study was to assess the effect of GWAS-identified genetic variants associated with birth weight on intrauterine fetal growth in 665 children. Fetal growth was estimated by two-dimensional ultrasound scans at 20, 25 and 32 weeks of gestation and growth trajectories were modeled using mixed linear regression. A genetic risk score (GRS) of birth weight-raising variants was associated with intrauterine growth showing an attenuating effect on the unconditional daily reduction in proportional weight gain of 8.92 × 10

Indexed as

Birth WeightFetal DevelopmentAdultBody Mass IndexDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseHumansHypertensionInfant, NewbornMalePregnancy

Identifiers

PMID29849051
PMCPMC5976727
OpenAlexW2807663727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.