Evidence map›Paper›PMID 29849039›Full record

Trial reportScientific reports2018

Oncological outcomes, quality of life outcomes and complications of partial cystectomy for selected cases of muscle-invasive bladder cancer.

Jan Ebbing, Robin Colja Heckmann, Justin William Collins, Kurt Miller, Barbara Erber, Frank Friedersdorff, Tom Florian Fuller, Jonas Busch, Hans Helge Seifert, Peter Ardelt and 4 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Age and risk of major complications in patients undergoing radical cystectomy for muscle invasive bladder cancer.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Bladder preservation in muscle-invasive bladder cancer: a comprehensive review.International braz j urol : official journal of the Brazilian Society of Urology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Jan EbbingUniversity Hospital Basel, Urological University Clinic Basel-Liestal, Spitalstrasse 21, 4056, Basel, Switzerland. jan.ebbing@usb.ch.
Robin Colja HeckmannUniversity Hospital Basel, Urological University Clinic Basel-Liestal, Spitalstrasse 21, 4056, Basel, Switzerland.
Justin William CollinsKarolinska Institutet, Department of Molecular Medicine and Surgery (MMK), Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden.
Kurt MillerCharité - University Hospital, Department of Urology, Chariteplatz 1, 10117, Berlin, Germany.
Barbara ErberVivantes Hospital Am Urban, Department of Urology, Dieffenbachstraße 1, 10967, Berlin, Germany.
Frank FriedersdorffCharité - University Hospital, Department of Urology, Chariteplatz 1, 10117, Berlin, Germany.
Tom Florian FullerCharité - University Hospital, Department of Urology, Chariteplatz 1, 10117, Berlin, Germany.
Jonas BuschCharité - University Hospital, Department of Urology, Chariteplatz 1, 10117, Berlin, Germany.
Hans Helge SeifertUniversity Hospital Basel, Urological University Clinic Basel-Liestal, Spitalstrasse 21, 4056, Basel, Switzerland.
Peter ArdeltUniversity Hospital Basel, Urological University Clinic Basel-Liestal, Spitalstrasse 21, 4056, Basel, Switzerland.
Christian WetterauerUniversity Hospital Basel, Urological University Clinic Basel-Liestal, Spitalstrasse 21, 4056, Basel, Switzerland.
Abolfazl HosseiniKarolinska University Hospital, Department of Urology, Solna, 171 76, Stockholm, Sweden.
Florian JentzmikOberschwaben Clinic, Hospital St. Elisabeth, Department of Urology, Elisabethenstr. 15, 88212, Ravensburg, Germany.
Carsten KempkensteffenCharité - University Hospital, Department of Urology, Chariteplatz 1, 10117, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEUniversity Hospital of Basel · CHKarolinska University Hospital · SESt. Elisabeth-Hospital Bochum · DEVivantes Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the oncological results, associated complications, and postoperative health-related quality of life (HR-QoL) in patients treated with partial cystectomy (PC) for muscle-invasive bladder cancer (MIBC). 27 patients who underwent open PC for cT2 MIBC were included. A simple Cox's proportional hazards regression model was used to assess the association of several potential prognostic factors with survival. Postoperative HR-QoL was assessed with the EORTC (European Organisation for the Research and Treatment of Cancer) QLQ-C30 questionnaire version 3.0. Final pathological tumour stages in PC specimen were: pT0: 18.5%, non-MIBC: 3.7%, MIBC: 74.1%, pCIS: 14.8%. Estimated 5-year overall- and progression-free survival rates were 53.7% and 62.1%. Five (18.5%) patients experienced local recurrence with MIBC. Overall, the salvage cystectomy rate was 18.5%. The 90-day mortality rate was 0%. Significant risk factors for progression-free survival were vascular invasion (HR 5.33) and tumour multilocularity (HR 4.5) in the PC specimen, and a ureteric reimplantation during PC (HR 4.53). The rates of intraoperative complications, 30- and 90-day major complications were 7.4%, respectively and 14.8% for overall long-term complications. Postoperatively, median (IQR) global health status and QoL in our PC cohort was 79.2 (52.1-97.9). Open PC can provide adequate cancer control of MIBC with good HR-QoL in highly selected cases. Open PC can lead to long-term bladder preservation and shows an acceptable rate of severe perioperative complications, even in highly comorbid patients.

Indexed as

Quality of LifeAgedCystectomyFemaleFollow-Up StudiesHumansMaleMiddle AgedMusclesNeoplasm InvasivenessPalliative CarePostoperative ComplicationsSurveys and QuestionnairesSurvival AnalysisTreatment OutcomeUrinary Bladder Neoplasms

Identifiers

PMID29849039
PMCPMC5976719
OpenAlexW2806042999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.