Evidence map›Paper›PMID 29849032›Full record

Trial reportScientific reports2018

Exercise training as a novel primary treatment for localised prostate cancer: a multi-site randomised controlled phase II study.

L Bourke, R Stevenson, R Turner, R Hooper, P Sasieni, R Greasley, D Morrissey, M Loosemore, A Fisher, H Payne and 2 more

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Inclusivity in prostate cancer and exercise research: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  4. Effects of exercise during active surveillance for prostate cancer: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  5. Pooled it
  6. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  7. Physical exercise and quality of life in patients with prostate cancer: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
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  19. A cost analysis of a community-based support centre for cancer patients and their families in Ireland: the EVeCANs study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

L BourkeHealth and Wellbeing, Sheffield Hallam University, Sheffield, UK. l.bourke@shu.ac.uk.
R StevensonAcute Therapy Services, Sheffield Teaching Hospitals, Sheffield, UK.
R TurnerHealth and Wellbeing, Sheffield Hallam University, Sheffield, UK.
R HooperCentre for Primary Care and Public Health, Queen Mary University of London, London, UK.
P SasieniWolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
R GreasleyHealth and Wellbeing, Sheffield Hallam University, Sheffield, UK.ORCID 0000-0002-4933-5165
D MorrisseyWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
M LoosemoreInstitute of Sport Exercise and Health, University College Hospitals, London, UK.
A FisherDepartment of Behavioural Science & Health, University College London, London, UK.
H PayneUniversity College Hospitals, London, UK.
S J C TaylorCentre for Primary Care and Public Health, Queen Mary University of London, London, UK.
D J RosarioDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

Funding

Cancer Research UK 14133Cancer Research UK 16892Cancer Research UK 16893Cancer Research UK 17309Department of Health CAT SCL-2013-04-003
6 · The paper itself

Abstract

Alternative management strategies for localised prostate cancer are required to reduce morbidity and overtreatment. The aim of this study was to evaluate the feasibility, safety and acceptability of exercise training (ET) with behavioural support as a primary therapy for low/intermediate risk localised prostate cancer. Men with low/intermediate-risk prostate cancer were randomised to 12 months of ET or usual care with physical activity advice (UCwA) in a multi-site open label RCT. Feasibility included acceptability, recruitment, retention, adherence, adverse events and disease progression. Secondary outcomes included quality of life and cardiovascular health indices. Of the 50 men randomised to ET (n = 25) or UCwA (n = 25), 92% (n = 46) completed 12 month assessments. Three men progressed to invasive therapy (two in UCwA). In the ET group, men completed mean: 140 mins per week for 12 months (95% CI 129,152 mins) (94% of target dose) at 75% Hrmax. Men in the ET group demonstrated improved body mass (mean reduction: 2.0 kg; 95% CI -2.9,-1.1), reduced systolic (mean: 13 mmHg; 95%CI 7,19) and diastolic blood pressure (mean:8 mmHg; 95% CI 5,12) and improved quality of life (EQ.5D mean:13 points; 95% CI 7,18). There were no serious adverse events. ET in men with low/intermediate risk prostate cancer is feasible and acceptable with a low progression rate to radical treatment. Early signals on clinically relevant markers were found which warrant further investigation.

Indexed as

ExerciseAgedFeasibility StudiesHumansMaleMotivationPatient ComplianceProstatic NeoplasmsRiskTreatment Outcome

Identifiers

PMID29849032
PMCPMC5976628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.