Observational studyNutrients2018
Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study.
Observational study in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Synergistic negative effect of selenium deficiency and thyroid dysfunction on cardiovascular disease in hemodialysis patients.Clinical and experimental nephrology · 2026Article
- Selenium Status Associates with Thyroid Hormone and Thyroid Dysfunction in Older Chinese Adults.Biological trace element research · 2025Article
- Relationship of comprehensive dietary antioxidant index and hypothyroidism risk: evidence from the National Health and Nutrition Examination Surveys 2007-2012.BMC endocrine disorders · 2025Article
- Selenium nutritional status and thyroid dysfunction.Archives of endocrinology and metabolism · 2025Review
- Selenium levels and their association with thyroid autoimmunity and severe preeclampsia in pregnancy: Insights from a prospective ideal breast milk cohort study.European thyroid journal · 2024Article
- Oxidative stress in Hashimoto's thyroiditis: possible adjuvant therapies to attenuate deleterious effects.Molecular and cellular biochemistry · 2023Review
- Selenium, Iodine and Iron-Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism.International journal of molecular sciences · 2023Review
- Relationship between dietary selenium intake and serum thyroid function measures in U.S. adults: Data from NHANES 2007-2012.Frontiers in nutrition · 2022Article
- Association between dietary onion intake and subclinical hypothyroidism in adults: a population-based study from an iodine-replete area.Endocrine · 2021Article
- Dietary patterns associated with subclinical atherosclerosis: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) study.Public health nutrition · 2021Article
- Multiple exposure pathways and health risk assessment of selenium for children in a coal mining area.Environmental science and pollution research international · 2021Article
- Role of Selenium Deficiency in Pediatrics with Acquired Hypothyroidism.International journal of preventive medicine · 2021Article
- Prenatal Maternal Low Selenium, High Thyrotropin, and Low Birth Weights.Biological trace element research · 2021Article
- The Impact of Trace Elements on Osteoarthritis.Frontiers in medicine · 2021Review
- Effect of Selenium-Enriched Yeast Supplementation on Serum Thyroid-Stimulating Hormone and Anti-Thyroid Peroxidase Antibody Levels in Subclinical Hypothyroidism: Randomized Controlled Trial.Advanced biomedical research · 2021Article
- The longitudinal effect of subclinical hypothyroidism on urine microalbumin-to-urine creatinine ratio in patients with type 2 diabetes mellitus.BMC endocrine disorders · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto-ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35⁻74 years. Dietary data was collected using a previously validated food frequency questionnaire. Subclinical hypothyroidism was categorized as thyroid-stimulating hormone levels of >4.0 IU/mL and free prohormone thyroxine levels within normal limits, without administering drugs for thyroid disease. A multiple logistic regression model was used to assess the relationship between the presence of subclinical hypothyroidism and tertiles of Se consumption. The prevalence of subclinical hypothyroidism in the study sample was 5.4% (95% confidence interval [CI], 3.8⁻7.0%). Compared with the first tertile of Se intake, the second (odds ratio [OR], 0.79; 95% CI, 0.65⁻0.96%) and third (OR, 0.72; 95% CI, 0.58⁻0.90%) tertiles were inversely associated with subclinical hypothyroidism, however further research is needed to confirm the involvement of Se in subclinical hypothyroidism using more accurate methodologies of dietary assessment and nutritional status to evaluate this relationship.
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